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Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation |
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| Authors: | Mahdavi Jafar Sondén Berit Hurtig Marina Olfat Farzad O Forsberg Lina Roche Niamh Angstrom Jonas Larsson Thomas Teneberg Susann Karlsson Karl-Anders Altraja Siiri Wadström Torkel Kersulyte Dangeruta Berg Douglas E Dubois Andre Petersson Christoffer Magnusson Karl-Eric Norberg Thomas Lindh Frank Lundskog Bertil B Arnqvist Anna Hammarström Lennart Borén Thomas |
| Institution: | Department of Odontology/Oral Microbiology, Ume? University, SE-901 87 Ume?, Sweden. |
| Abstract: | Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection. |
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