| TLR7配体Loxoribine对调节性T细胞抑制作用的解除 |
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| 引用本文： | 唐宗青.TLR7配体Loxoribine对调节性T细胞抑制作用的解除[J].上海交通大学学报(农业科学版),2007,25(6):525-530,565. |
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| 作者姓名： | 唐宗青 |
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| 作者单位： | 江苏省兴化市人民医院检验科,兴化,225700 |
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| 摘 要： | 调节性T细胞是机体免疫功能的重要调节因素,近年来的研究提示Toll样受体可以直接或间接的调控调节性T细胞的抑制功能。作者的研究显示:在CD4、Treg和DC反应体系中加入TLR7配体Loxoribine后CD4 T细胞的增殖增强,Treg的抑制功能丧失;进一步用Loxoribine分别处理CD4 T细胞、Treg、和DC细胞后发现,Loxoribine处理的DC,一方面使CD4 T细胞增殖增强,一方面使Treg抑制功能丧失;且通过trans-well试验证明Loxoribine作用于DC使Treg抑制功能丧失是通过DC释放的可溶性分子介导的,而不是通过细胞与细胞之间的接触来实现的。
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| 关 键 词： | 调节性T细胞 Toll样受体7 淋巴细胞活化 |
| 文章编号： | 1671-9964（2007）06-0525-06 |
| 收稿时间： | 2007-09-09 |
| 修稿时间： | 2007年9月9日 |
TLR7 Ligand Loxoribine Inhibit the Suppressive Function of Regulatory T Cell |
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| TANG Zong-qing.TLR7 Ligand Loxoribine Inhibit the Suppressive Function of Regulatory T Cell[J].Journal of Shanghai Jiaotong University (Agricultural Science),2007,25(6):525-530,565. |
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| Authors: | TANG Zong-qing |
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| Abstract: | Regulatory T cells play a very pivotal role in regulating the immune function,recently,growing evidence suggest that Toll-like receptors can directly or indirectly regulate the immune suppressive function of regulatory T cell.Our present research demonstrated that the proliferation of CD4 T cell was enhanced after TLR7 ligand(Loxoribine) was added into the CD4,Treg and DC mixture reaction system and the suppressive function of regulatory T cell was refractoried.The extensively study showed that Loxoribine pre-treated DCs could not only increase the proliferation of CD4 T cells,but also inhibit the suppressive function of regulatory T cells.Trans-well experiment further displayed that Loxoribine-treated DCs refractoried the suppressive function of regulatory T cell is meditated by some soluble factors,but not through cell-cell contact. |
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| Keywords: | Loxoribine |
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