| 冬凌草内生真菌抗肿瘤活性菌株筛选 |
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| 引用本文： | 高蓬明.冬凌草内生真菌抗肿瘤活性菌株筛选[J].安徽农业科学,2008,36(29). |
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| 作者姓名： | 高蓬明 |
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| 作者单位： | 贵阳学院生物与环境工程系,贵州贵阳,550005 |
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| 摘 要： | 目的]筛选冬凌草内生真菌抗肿瘤活性菌株,为开发利用冬凌草内生真菌资源提供依据。方法]以药用植物冬凌草为试验材料,分离筛选能产抗肿瘤活性物质的内生真菌。通过组织分离法,从贵州省施秉县产冬凌草中分离到152株植物内生真菌,利用抗肿瘤体外细胞增殖抑制筛选模型(SRB法)对其进行活性检测。结果]结果表明,20株内生真菌(占总分离菌株的13.1%)对人慢性髓性白血病K562细胞具有显著的增殖抑制活性。结论]冬凌草内生真菌是寻找抗肿瘤活性代谢产物的良好资源。
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| 关 键 词： | 冬凌草 内生真菌 抗肿瘤 筛选 |
Screening of Antitumor Strains from Endophytic Fungi in Rabdosia rubescens |
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| GAO Peng-ming.Screening of Antitumor Strains from Endophytic Fungi in Rabdosia rubescens[J].Journal of Anhui Agricultural Sciences,2008,36(29). |
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| Authors: | GAO Peng-ming |
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| Abstract: | Objective] The research aimed to screen the antitumor strains from endophytic fungi in Rabdosia rubescens and provide the basis for exploring and utilizing endophytic fungi resources.Method] 152 strains of endophytic fungi were isolated from Rabdosia rubescens in Shibing County of Guizhou Province.And their fermented products were screened with K562 cells by SRB method.Result] The results showed that 20 strains had cell proliferation inhibitory activity on K562 cells,which possessed 13.1% of total 152 strains tested.Conclusion] Endophytic fungi from Rabdosia rubescens are well resources for researching antitumor metabolites. |
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| Keywords: | Rabdosia rubescens Endophytic fungi Antitumor Screening |
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