| 口蹄疫病毒病毒样颗粒研究进展 |
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| 引用本文： | 张庆勋,刘新生,周鹏,方玉珍,王永录,张永光.口蹄疫病毒病毒样颗粒研究进展[J].中国畜牧兽医,2014,41(11):258-262. |
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| 作者姓名： | 张庆勋 刘新生 周鹏 方玉珍 王永录 张永光 |
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| 作者单位： | 中国农业科学院兰州兽医研究所, 家畜疫病病原生物学国家重点实验室, 国家口蹄疫参考实验室, 甘肃兰州 730046 |
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| 基金项目： | 十二五863计划"家畜口蹄疫新型疫苗研制与生产工艺创新"(2011AA10A211);重大动物疫病疫苗临床免疫评价技术研究与示范(201203039);国家生猪产业体系项目(CARS-36-06B);甘肃省国际科技合作计划(1011WCGA160)。 |
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| 摘 要： | 口蹄疫病毒病毒样颗粒(virus-like particles,VLPs)是不含口蹄疫病毒RNA的空衣壳结构,由口蹄疫病毒的4种结构蛋白体外自组装形成的,形态上与天然病毒粒子相似,具有很强的免疫原性和生物学活性。文章介绍了口蹄疫病毒衣壳的组装、口蹄疫病毒VLPs在国内外的研究进展和影响VLPs形成的因素,并对VLPs在疫苗研制等方面的应用前景作了展望。
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| 关 键 词： | 口蹄疫病毒 病毒样颗粒 组装 疫苗 |
| 收稿时间： | 2014-05-05 |
Research Progress on Foot-and-mouth Disease Virus Virus-like Particles |
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| ZHANG Qing-xun,LIU Xin-sheng,ZHOU Peng,FANG Yu-zhen,WANG Yong-lu,ZHANG Yong-guang.Research Progress on Foot-and-mouth Disease Virus Virus-like Particles[J].China Animal Husbandry & Veterinary Medicine,2014,41(11):258-262. |
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| Authors: | ZHANG Qing-xun LIU Xin-sheng ZHOU Peng FANG Yu-zhen WANG Yong-lu ZHANG Yong-guang |
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| Institution: | National Foot and Mouth Disease Reference Laboratory, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, CAAS, Lanzhou 730046, China |
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| Abstract: | Foot-and-mouth disease virus (FMDV) virus-like particles (VLPs) are particles lack virus-specific genetic materials (RNA), which are self-assembled by four structural proteins and are similar to natural virus particles in morphology. Also, VLPs have better biological activity and immunogenicity. This review focuses on the assembly of FMDV capsid, advances on VLPs, the influencing factors of forming VLPs, and the prospect of the development and application of FMDV VLPs vaccines. |
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| Keywords: | foot-and-mouth disease virus virus-like particles (VLPs) assembly vaccines |
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