| 牛磺鹅去氧胆酸对家禽和小鼠抗热应激作用研究 |
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| 引用本文： | 付长其,夏俊峰,李金莲,周德方,王健丞,石有斐.牛磺鹅去氧胆酸对家禽和小鼠抗热应激作用研究[J].中国畜牧兽医,2014,41(10):129-134. |
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| 作者姓名： | 付长其 夏俊峰 李金莲 周德方 王健丞 石有斐 |
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| 作者单位： | 1. 山东农业大学动物科技学院, 山东泰安 271018;2. 泰山学院生物与酿酒工程学院, 山东泰安 271021 |
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| 基金项目： | 国家自然科学基金(30800837);山东省博士后基金(36616);山东农业大学青年科技创新基金(23616) |
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| 摘 要： | 为探讨牛磺鹅去氧胆酸(taurochenodeoxycholic acid,TCDCA)对热应激条件下AA肉鸡、海兰褐仔鸡及昆明种小白鼠的抗热应激作用,试验检测了TCDCA对热应激条件下AA肉鸡死亡率、海兰褐仔鸡体增重及对热应激小鼠采食量、饮水量、增重、血清中皮质醇和甲状腺素(T3)含量、肝脏组织中热休克蛋白70(HSP70) mRNA表达的影响。结果表明,0.1和0.2 g/kg TCDCA可显著降低热应激AA肉鸡死亡率(P<0.05);0.05、0.1和0.2 g/kg TCDCA可极显著增加热应激海兰褐仔鸡的体增重(P<0.01);0.1 g/kg TCDCA能显著提高热应激小鼠的采食量和饮水量(P<0.05),而对其体增重无显著影响(P>0.05);0.05、0.1和0.2 g/kg TCDCA可使热应激小鼠血清T3含量显著降低(P<0.05);0.1和0.2 g/kg TCDCA可使热应激小鼠血清皮质醇含量显著升高(P<0.05);0.05、0.1和0.2 g/kg TCDCA可显著抑制热应激小鼠肝脏中HSP70 mRNA的表达(P<0.05)。综上所述,TCDCA具有抗热应激作用。
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| 关 键 词： | 牛磺鹅去氧胆酸 抗热应激 内分泌 HSP70 |
| 收稿时间： | 2014-02-24 |
Study on Effect of Taurochenodeoxycholic Acid on Heated-stressed Poultry and Mice |
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| FU Chang-qi,XIA Jun-feng,LI Jin-lian,ZHOU De-fang,WANG Jian-cheng,SHI You-fei.Study on Effect of Taurochenodeoxycholic Acid on Heated-stressed Poultry and Mice[J].China Animal Husbandry & Veterinary Medicine,2014,41(10):129-134. |
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| Authors: | FU Chang-qi XIA Jun-feng LI Jin-lian ZHOU De-fang WANG Jian-cheng SHI You-fei |
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| Institution: | 1. College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China;2. Department of Biological and Brewing Engineering, Taishan University, Tai'an 271021, China |
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| Abstract: | In order to investigate the efficacy of TCDCA on heated-stressed Hyline brown chicken,AA meat chicken and Kunming mice,examined the effects of TCDCA on the mortality of AA meat chicken,the increase in body weight of Hyline brown chicken as well as mice's food intake,water intake,serum hydrocortisone and T3 concentrations and HSP70 mRNA expression in hepatic tissues under heat stress.The results showed that TCDCA (0.1 and 0.2 g/kg) significantly reduced the mortality of heated-stressed AA meat chicken (P<0.05).TCDCA (0.05,0.1 and 0.2 g/kg) extremely significantly increased the weight of heated-stressed Hyline brown chicken (P<0.01).TCDCA (0.1 g/kg) significantly increased the intake of food and water on heated-stressed mice (P<0.05),but it had no effect on weight of heated-stressed mice (P>0.05).TCDCA (0.05,0.1 and 0.2 g/kg) significantly decreased the concentration of serum T3 on heated-stressed mice (P<0.05).TCDCA (0.1 and 0.2 g/kg) significantly increased the concentration of serum hydrocortisone on heated-stressed mice (P<0.05).TCDCA (0.05,0.1 and 0.2 g/kg) significantly inhibited the expression of HSP70 mRNA in hepatic tissues on heated-stressed mice (P<0.05).The results as mentioned above indicated that TCDCA could prevent the thermal stress. |
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| Keywords: | taurochenodeoxycholic acid anti-heat stress endocrine HSP70 |
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