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| 板黄口服液在靶动物鸡中的安全性研究 | |
| 引用本文： | 王永彬,周绪正,张继瑜.板黄口服液在靶动物鸡中的安全性研究[J].中国畜牧兽医,2014,41(9):126-131. |
| 作者姓名： | 王永彬 周绪正 张继瑜 |
| 作者单位： | 1. 中国农业科学院兰州畜牧与兽药研究所, 农业部兽用药物创制重点实验室, 甘肃省新兽药工程重点实验室, 甘肃兰州 730050; 2. 西藏自治区兽医生物药品制造厂, 西藏拉萨 850004 |
| 基金项目： | 国家现代农业肉牛牦牛技术体系（nycytx-38）；公益性行业（农业）科研专项“防治畜禽卫气分证中兽药生产关键技术研究与应用”（201303040-09）。 |
| 摘 要： | 本研究按板黄口服液临床推荐剂量的1（1%）、3（3%）、5（5%）、10（10%）倍连续给药21 d，对给药后靶动物鸡的临床血液学、血液生化学、脏器系数和组织病理学方面的数据与对照组进行比较，应用SPSS 17.0软件进行t检验，统计分析组间各指标的差异显著性，为其临床应用的安全性提供数据资料；试验结果显示与对照组相比，各板黄口服液剂量组靶动物鸡的临床血液学、血液生化学、增重和脏器系数等指标差异均不显著（P>0.05）。试验结果表明10倍推荐剂量（10%）板黄口服液对靶动物鸡是安全的。 |
| 关 键 词： | 板黄口服液 血液生化 组织病理 |
| 收稿时间： | 2014-03-07 |
Safety Studies on Radix isatidis and Rhizoma coptidis Oral Liquid in Target Animal Chicken |
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| WANG Yong-bin,ZHOU Xu-zheng,ZHANG Ji-yu.Safety Studies on Radix isatidis and Rhizoma coptidis Oral Liquid in Target Animal Chicken[J].China Animal Husbandry & Veterinary Medicine,2014,41(9):126-131. | |
| Authors: | WANG Yong-bin ZHOU Xu-zheng ZHANG Ji-yu |
| Institution: | 1. Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of New Veterinary Pharmaceutics Discovery, Ministry of Agriculture, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics, Chinese Academy of Agriculture Sciences, Lanzhou 730050, China; 2. Veterinary Biological Pharmaceutical Factory of Tibet Autonomous Region, Lhasa 850004, China |
| Abstract: | In this study, we administrated Radix isatidis and Rhizoma coptidis oral liquid according to 1(1%), 3(3%), 5(5%) and 10(10%) times of the clinical recommended doses for 21 days, and got the data about clinical hematology, blood biochemistry, organ index and histopathology of Radix isatidis and Rhizoma coptidis oral liquid in the target animal chicken. Then we preceded t test using SPSS 17.0 software and analyzed the statistical significance of inter-group indexes to provide the relevant data for the safety of clinical application. The experimental results showed that there was no significant difference about the relevant data of Radix isatidis and Rhizoma coptidis oral liquid in the target animal chicken compared with control group (P>0.05), and Radix isatidis and Rhizoma coptidis oral liquid would be safe at 10 times of the recommended dose (10%) in the target animal chicken. |
| Keywords: | Radix isatidis and Rhizoma coptidis oral liquid blood biochemistry histopathology |
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