Protective effect of emodin on lung injury induced by hepatic fibrosis in rats |
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| Authors: | ZHANG Li-li ZHANG Hui-ying WANG Li-min LI Xu-jiong JIA Jian-tao L Min-li FAN Yi-min ZHAN Cui-ying LIU Ming-she ZHAO Zhong-fu HAN De-wu CHENG Ji |
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| Institution: | 1.Department of Pathophysiology, 2Functional Integrative Laboratory, 3Department of Physiology, 5Institute of Hepatology, Changzhi Medical College, Changzhi 046000, China;4.ICU of The Second Hospital, 6Institute of Hepatology, Shanxi Medical University, Taiyuan 030001, China;7.Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. |
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| Abstract: | AIM:To explore the protective effect of emodin on lung injury induced by hepatic fibrosis in rats. METHODS:The hepatic fibrosis rat model was established with multiple pathogenic factors (CCl 4, ethanol, high fat, high cholesterol and low choline) and treated with different doses (20 mg/kg and 40 mg/kg) of emodin for 4 weeks. The hepatic index was measured. The biochemical indexes, endotoxin, homocysteine, albumin, aspartate aminotransferase,alanine aminotransferase, total bilirubin, total cholesterol and triglyceride, and hepatic fibrosis indexes, hyaluronic acid, laminin, collagen IV and procollagen Ⅲ, were detected. The histopathological changes of the liver were observed. The pulmonary index was determined. The histopathological changes of the lungs were observed. The levels of tumor necrosis factor α (TNF-α), malondialdehyde (MDA), nitric oxide (NO) and peroxynitrite (ONOO-) in the lung tissues were analyzed. RESULTS:The rat hepatic fibrosis model was successfully established. In model group, lung edema and inflammation occurred, and the pulmonary index and the levels of TNF-α, MDA, NO and ONOO- in the lung tissues were increased significantly. In emodin treatment groups, the pulmonary indexes were lower than that in model group. The pathological injury of the lung tissues was alleviated. The levels of TNF-α, MDA, NO and ONOO- in the lung tissues were decreased. CONCLUSION:Emodin has a protective effect on lung injury induced by hepatic fibrosis in rats. |
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| Keywords: | Emodin Liver fibrosis Hepatopulmonary syndrome Lung injury |
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