| 基于防突变浓度的新型药动学-药效学-突变选择窗同步模型在临床用药上的指导作用 |
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| 引用本文： | 廖雪玲,张炳旭,丁焕中.基于防突变浓度的新型药动学-药效学-突变选择窗同步模型在临床用药上的指导作用[J].中国畜牧兽医,2013,40(1):199-203. |
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| 作者姓名： | 廖雪玲 张炳旭 丁焕中 |
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| 作者单位： | 1. 上海公谊兽药厂, 上海 201401;2. 华南农业大学兽医学院, 广东广州 510642 |
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| 基金项目： | 国家自然科学基金资助项目(31172366) |
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| 摘 要： | 文章综述了抗菌药药动学/药效学(PK/PD)模型的发展,详细阐述新型药动物学/药效学模型在抑制细菌耐药突变上的作用,为合理用药及新药研发提供指导,并指出了临床应用所存在的问题。
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| 关 键 词： | 药动学/药效学模型 突变选择窗 耐药性 合理用药 |
| 收稿时间： | 2012-06-30 |
Instruction Function in Drug Administration on the New PK-PD-MSW Modeling Based on Mutant Prevent Concentration |
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| LIAO Xue-ling
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ZHANG Bing-xu
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DING Huan-zhong.Instruction Function in Drug Administration on the New PK-PD-MSW Modeling Based on Mutant Prevent Concentration[J].China Animal Husbandry & Veterinary Medicine,2013,40(1):199-203. |
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| Authors: | LIAO Xue-ling ZHANG Bing-xu DING Huan-zhong |
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| Institution: | 1. Shanghai Gongyi Veterinary Medicines Plant, Shanghai 201401, China;2. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China |
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| Abstract: | Development history of pharmacokinetic/pharmacodynamic(PK/PD) model for antimicrobial drugs was reviewed in the present article, including the important role of new PK/PD model in inhibition bacterial resistance mutation, intruction in the rational design of drug regimen and new drug investigation. In addition, problems of clinical application of PK/PD model were also discussed. |
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| Keywords: | PK/PD model mutant selection window resistance rational drug administration |
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