Serum and Colostral Antibody Responses of Pregnant Mares to Salmonella Bacterins and Colostral Antibody Transfer to Their Foals |
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| Authors: | Christopher Scott Bailey Luke Fallon Wei Wang Luke Borst John Timoney |
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| Institution: | 1. Department of Clinical Sciences, NCSU, College of Veterinary Medicine, Raleigh, NC;2. Hagyard Equine Medical Institute, Iron Works Pike, Lexington, KY;3. Department of Veterinary Sciences, Gluck Equine Research Center, University of Kentucky, Lexington, KY;4. Department of Population Health and Pathobiology, NCSU, College of Veterinary Medicine, Raleigh, NC |
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| Abstract: | Salmonella spp. are well-recognized foal pathogens. However, prevention of neonatal salmonellosis by vaccinating pregnant mares has not been reported previously. A formalinized adjuvanted bacterin of Salmonella enterica, serovar typhimurium (S typhimurium) and serovar newport (S newport), was given to pregnant mares to determine its safety (study 1) and potency in enhancing Salmonella-specific antibody for colostral transfer to foals (study 2). Antibody levels to S typhimurium (lysate and lipopolysaccharide LPS]) and S newport (lysate) were determined by enzyme-linked immunoassay and reported as optical density measures. The mares in study 1 (n = 16) exhibited minimal reactions to the bacterin, and pregnancy was maintained in all mares throughout the study period. In study 2, serum antibody levels to both S typhimurium and S newport increased significantly in vaccinated mares (mean OD increase: 0.83 ± 0.58 lysate of S typhimurium], 1.27 ± 0.82 LPS of S typhimurium], and 0.67 ± 0.74 lysate of S newport], respectively; n = 28). Elevated serum antibody levels on day 28 correlated with high antibody levels in colostrum (r2 = 0.62-0.75; P < .0001) and in serum samples of foals (r2 = 0.5-0.73; P < .001). |
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| Keywords: | Salmonella Maternal vaccination Foal Antibody |
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