Changes in metabolite, energy metabolism related enzyme activities and peripheral blood mononuclear cell (PBMC) Populations in beef heifers with two differing liveweight change profiles in New Zealand |
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| Authors: | A Mori P R Kenyon N Mori I Yamamoto Y Tanaka N Suzuki H Tazaki T Ozawa T Hayashi R E Hickson S T Morris H Blair T Arai |
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| Institution: | (1) Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino Tokyo, 180-8602, Japan;(2) Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Life Science University, Tokyo, Japan;(3) Research Institute for Biological Science, Tokyo University of Science, Chiba, Japan;(4) Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand |
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| Abstract: | Metabolite and immunoreactive insulin (IRI) concentrations, energy metabolism related enzymes activities and peripheral blood
mononuclear cell (PBMC) populations were measured in blood of pregnant Angus heifers with differing liveweight change profiles
(gaining or losing), in New Zealand to investigate the meanings of those parameters in the restricted feeding beef heifers.
Beef heifers losing liveweight (−412 g/day) showed significantly lower concentrations of plasma IRI, and higher concentrations
of plasma free fatty acid (FFA) than heifers gaining liveweight (483 g/day). The cytosolic and mitochondrial malate dehydrogenase
(MDH) activities and MDH/lactate dehydrogenase (M/L) ratio in leukocytes of the liveweight losing heifers were significantly
higher than those the liveweight gaining heifers. Percentages of cluster of differentiation (CD) 3 positive cells and natural
killer (NK) cells in PBMC decreased significantly in the liveweight losing heifers compared to those in the liveweight gaining
heifers. Plasma IRI and FFA concentrations, leukocyte cytosolic and mitochondrial MDH activities and CD3 positive and NK cell
populations may be useful markers to evaluate metabolic conditions and immunity in the restricted feeding beef heifers. |
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| Keywords: | Beef heifer CD3 cell Liveweight MDH Metabolite |
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