| 赭曲霉毒素A对肉鸡毒性作用的研究进展 |
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| 引用本文： | 赭曲霉毒素A对肉鸡毒性作用的研究进展.赭曲霉毒素A对肉鸡毒性作用的研究进展[J].畜牧与饲料科学,2021,42(3):47-52. |
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| 作者姓名： | 赭曲霉毒素A对肉鸡毒性作用的研究进展 |
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| 作者单位： | 河南农业大学动物医学院,河南 郑州 450002 |
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| 基金项目： | 中国博士后科学基金面上资助项目（2020M672234）; 河南省高等学校重点科研项目计划（21A230013） |
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| 摘 要： | 霉菌毒素污染是影响动物饲料安全的重要因素。赭曲霉毒素A（ochratoxin A,OTA）广泛存在于肉鸡饲料原料中。众多研究表明,OTA对肉鸡具有肾毒性、肝毒性、细胞毒性、遗传毒性、致癌性、致畸性、免疫毒性和肠道毒性等,给肉鸡养殖业带来了巨大的经济损失,也对动物和人类的健康造成威胁。对国内外OTA研究进展进行总结归纳,从诱导机体产生肠毒性、肝毒性、肾毒性和免疫毒性四方面阐述OTA对肉鸡的致毒机制,为深入研究OTA提供参考。
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| 关 键 词： | 赭曲霉毒素A 肉鸡 致毒机制 |
| 收稿时间： | 2021-01-19 |
Research Advances of the Toxicity of Ochratoxin A on Broiler Chickens |
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| YUE Ke,XU Ting-ting,CAO Qin-qin,LIN Lu-xi,ZHANG Chao-dong,ZHENG Jing-jing,TONG Zong-xi,HUANG Shu-cheng.Research Advances of the Toxicity of Ochratoxin A on Broiler Chickens[J].Animal Husbandry and Feed Science,2021,42(3):47-52. |
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| Authors: | YUE Ke XU Ting-ting CAO Qin-qin LIN Lu-xi ZHANG Chao-dong ZHENG Jing-jing TONG Zong-xi HUANG Shu-cheng |
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| Institution: | College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450002,China |
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| Abstract: | Mycotoxin contamination is an important factor that affects the animal feed safety. Ochratoxin A （OTA） is widely distributed in feed raw materials for broiler chickens. Numerous studies have shown that OTA has nephrotoxicity, hepatotoxicity, cytotoxicity, genetic toxicity, carcinogenicity, teratogenicity, immunotoxicity and intestinal toxicity on broiler chickens, which not only brings great economic losses to broiler chickens rearing industry, but also poses a threat to animal and human health. In this paper, the research advances of OTA in China and abroad are summarized but reviewed, and its toxic mechanisms on broiler chickens are expounded from the aspects of intestinal toxicity, hepatotoxicity, nephrotoxicity and immunotoxicity induced by OTA, in hoping to provide references for further study of OTA. |
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| Keywords: | Ochratoxin A broiler chickens toxic mechanism |
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