| 山奈酚对三硝基丙酸诱导氧化应激胎鼠的影响 |
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| 引用本文： | 高见红,白煜,于佳彤,王慧瑞,刘旭,方南洙,柳海星.山奈酚对三硝基丙酸诱导氧化应激胎鼠的影响[J].饲料研究,2021(2):58-61. |
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| 作者姓名： | 高见红 白煜 于佳彤 王慧瑞 刘旭 方南洙 柳海星 |
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| 作者单位： | 延边大学农学院;延边州畜牧总站 |
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| 基金项目： | 国家自然基金项目“氧化应激诱导的母型-合子型时期哺乳动物胚胎发育阻滞机理的研究(项目编号:32060756)”。 |
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| 摘 要： | 试验旨在研究山奈酚对三硝基丙酸诱导亲代小鼠氧化应激从而对子代胎鼠氧化应激和抗氧化能力的作用。42只亲代小鼠分为3组:对照组、氧化应激模型组、抗氧化剂组,试验重复3次。测定妊娠20 d后的子代胎鼠肝脏、肺脏和心脏3个器官中的总超氧化物歧化酶(T-SOD)活力、谷胱甘肽过氧化物酶(GSH-Px)活力、总抗氧化能力(T-AOC)、丙二醛(MDA)含量和过氧化氢酶(CAT)活力。结果显示,山奈酚显著代偿降低子代胎鼠心、肝、肺相关抗氧化酶的活力(P<0.05),显著降低氧化应激产物的含量(P<0.05)。研究表明,山奈酚对于由三硝基丙酸诱导的亲代小鼠氧化应激模型的子代胎鼠氧化应激情况具有一定的抗氧化作用。
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| 关 键 词： | 胎鼠 山奈酚 三硝基丙酸 氧化应激 抗氧化性能 |
Effect of kaempferol on oxidative stress induced by trinitropropionic acid in fetal rats |
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| GAO Jian-hong,BAI Yu,YU Jia-tong,WANG Hui-rui,LIU Xu,FANG Nan-zhu,LIU Hai-xing.Effect of kaempferol on oxidative stress induced by trinitropropionic acid in fetal rats[J].Feed Research,2021(2):58-61. |
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| Authors: | GAO Jian-hong BAI Yu YU Jia-tong WANG Hui-rui LIU Xu FANG Nan-zhu LIU Hai-xing |
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| Abstract: | The aim of the study was to investigate the effect of kaempferol on oxidative stress induced by trinitropropionic acid in parental mice and its effect on oxidative stress and antioxidant capacity in offspring fetal mice. 42 parental mice were divided into three groups: the control group, the oxidative stress model group and the antioxidant group. The experiment was repeated three times. The activity of total superoxide dismutase(T-SOD), glutathione peroxidase(GSH-PX), total antioxidant capacity(T-AOC), malondialdehyde(MDA) content and catalase(CAT) in the liver, lung and heart of fetal rats after 20 d gestation were measured. The results showed that kaempferol significantly reduced the activities of antioxidant enzymes related to heart, liver and lung(P<0.05), and significantly reduced the content of oxidative stress products(P<0.05). It is concluded that kaenophenol has certain antioxidant effect on oxidative stress in the offspring of parental mouse model induced by trinitropropionic acid, and has positive effects on alleviating oxidative stress in the offspring of parental mouse model induced by trinitropropionic acid. |
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| Keywords: | fetal rats kaempferol trinitropropionic acid oxidative stress antioxidant capacity |
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