Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale |
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| Authors: | Sachiko Tsukamoto Keiichirou Koimaru Tomihisa Ohta |
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| Institution: | Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan |
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| Abstract: | A new oxazole-containing proteasome inhibitor, secomycalolide A, together with known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge of the genus Mycale. They showed proteasome inhibitory activities with IC50 values of 11–45 μg/mL. |
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| Keywords: | proteasome inhibitor secomycalolide A mycalolide A marine sponge Mycale |
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