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Anti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii |
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| Authors: | Costa José Fernando Oliveira Kiperstok Alice Costa David Juceni Pereira de Lima David Jorge Maurício Giulietti Ana Maria de Queiroz Luciano Paganucci dos Santos Ricardo Ribeiro Soares Milena Botelho Pereira |
| Institution: | José Fernando Oliveira Costa, Alice Costa Kiperstok, Juceni Pereira de Lima David, Jorge Maurício David, Ana Maria Giulietti, Luciano Paganucci de Queiroz, Ricardo Ribeiro dos Santos,Milena Botelho Pereira Soares, |
| Abstract: | Ethyl acetate and chloroform extracts from aerial parts of Portulaca werdermannii and P. hirsutissima were tested in lymphoproliferation assays and axenic cultures of Leishmania amazonensis and Trypanosoma cruzi. Both extracts of P. werdermannii and P. hirsutissima had a potent inhibitory activity on lymphocyte proliferation. On the contrary, only the chloroformic extract of both plants inhibited L. amazonensis growth, without effect on T. cruzi cultures. These results indicate these Portulaca species as potential sources of new active molecules for the treatment of leishmaniasis and immune-mediated pathologies. |
| Keywords: | Portulaca werdermannii Portulaca hirsutissima Anti-protozoal activity Immunomodulatory activity |
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