Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders |
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| Authors: | Mariano Catanesi Giulia Caioni Vanessa Castelli Elisabetta Benedetti Michele d&#x;Angelo Annamaria Cimini |
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| Institution: | 1.Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, AQ, Italy; (M.C.); (G.C.); (V.C.); (E.B.);2.Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA |
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| Abstract: | Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to survive from atypical environmental conditions, such as oxidative stress, photodynamic damage, and extreme temperature. Recent evidence proposed a beneficial role of these compounds for human health. In particular, xanthines, bryostatin, and 11-dehydrosinulariolide displayed encouraging neuroprotective effects in neurodegenerative disorders. This review will focus on the most promising marine drugs’ neuroprotective potential for neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. We will describe these marine compounds’ potential as adjuvant therapies for neurodegenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties. |
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| Keywords: | marine drugs neurodegenerative diseases Parkinson’ s disease Alzheimer’ s disease brain antioxidants |
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