| 乙草胺对热带爪蟾的早期致畸效应及遗传毒性研究 |
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| 引用本文： | 李贤宾,李少南,袁丙强,朱国念.乙草胺对热带爪蟾的早期致畸效应及遗传毒性研究[J].农药学学报,2011,13(1):40-46. |
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| 作者姓名： | 李贤宾 李少南 袁丙强 朱国念 |
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| 作者单位： | 1.浙江大学 农药与环境毒理研究所,杭州 310029 |
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| 基金项目： | 浙江省自然科学基金(Y307448) |
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| 摘 要： | 为了评价乙草胺对热带爪蟾Xenopus tropicalis早期发育阶段的影响,采用爪蟾胚胎致畸试验 (FETAX) 测定了乙草胺对爪蟾胚胎发育的致畸效应。结果表明,乙草胺对热带爪蟾胚胎的致畸中浓度(TC50) 为有效成分1.20 mg/L,且能引起爪蟾腹部水肿、面部畸形、脊柱弯曲、尾巴弯曲、头部畸形等多种胚胎畸形。乙草胺的致畸指数(TI) 为1.88,具有潜在的致畸风险。爪蟾蝌蚪在亚致死浓度的乙草胺中暴露4 d后,微核和单细胞凝胶电泳试验结果显示,乙草胺可导致蝌蚪血细胞的微核率显著升高,其尾部DNA含量和Olive 尾矩两个指标也均显示细胞DNA受到损伤,且随着药剂浓度的增加,对DNA的损伤程度增强。
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| 关 键 词： | 乙草胺 热带爪蟾 致畸效应 DNA损伤 |
| 收稿时间： | 2010/5/11 0:00:00 |
| 修稿时间： | 2010/7/18 0:00:00 |
Teratogenic effect and genotoxicity of acetochlor on embryos and tadpoles of West-African clawed frog (Xenopus tropicalis) |
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| LI Xian-bin,LI Shao-nan,YUAN Bing-qiang and ZHU Guo-nian.Teratogenic effect and genotoxicity of acetochlor on embryos and tadpoles of West-African clawed frog (Xenopus tropicalis)[J].Chinese Journal of Pesticide Science,2011,13(1):40-46. |
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| Authors: | LI Xian-bin LI Shao-nan YUAN Bing-qiang and ZHU Guo-nian |
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| Institution: | 1.Institute of Pesticide and Environmental Toxicology,Zhejiang University,Hangzhou 310029,China |
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| Abstract: | In order to assess the developmental toxicity and genotoxicity of acetochlor on the early development of Xenopus tropicalis,the teratogenicity on embryos exposed to acetochlor was investigated by modified frog embryo teratogenesis assay-Xenopus(FETAX).The teratogenic median concentration(TC50) value of acetochlor was 1.20 mg(a.i)/L.Acetochlor could induce a variety of malformations on X.tropicalis embryos,such as facial abnormality,pericardial edema,notochord and tail flexures,cephalic dysplasia and gut mal... |
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| Keywords: | acetochlor Xenopus tropicalis teratogenic effect DNA damage |
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