Neuroprotective Effects of Longan ( Dimocarpus longan Lour.) Flower Water Extract on MPP(+)-Induced Neurotoxicity in Rat Brain |
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| Authors: | Anya Maan-Yuh Lin Liang-Yi Wu Kai-Chih Hung Hui-Ju Huang Yen Ping Lei Wen-Chien Lu Lucy Sun Hwang |
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| Institution: | Institute of Pharmacology, National Yang-Ming University , Taipei, Taiwan. |
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| Abstract: | In this study, the neuroprotective effect of Dimocarpus longan Lour. flower water extract (LFWE) was investigated. First, an in vitro study showed that LFWE concentration-dependently inhibited lipid peroxidation of brain homogenates incubated at 37 °C. The antioxidative activity of LFWE was more potent than that of glutathione or Trolox. Furthermore, an ex vivo study found that the basal lipid peroxidation (0 °C) and lipid peroxidation incubated at 37 °C were lower in the brain homogenates of LFWE-treated (500 mg/day) rats, indicating that the brain of LFWE-treated rats was more resistant to oxidative stress. Moreover, a Parkinsonian animal model was employed to demonstrate that oral administration of LFWE (125-500 mg/kg/day) dose-dependently attenuated 1-methyl-4-phenylpyridinium (MPP(+))-induced neurotoxicity in the nigrostriatal dopaminergic system of rat brain. In conclusion, this study suggests that LFWE is antioxidative, anti-inflammatory, and anti-apoptotic. Furthermore, oral administration of LFWE appears to be useful in preventing and/or treating central nervous system neurodegenerative diseases, including Parkinsonism. |
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