Hormonal response to dobutamine cardiac stress testing in a conscious canine model of early left ventricular dysfunction induced by chronic rate overload |
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| Authors: | K Mc Entee DVM PhD dipl ECVIM-CA C Clercx DVM PhD Dipl ECVIM-CA T Flandre DVM E Jonville DVM C Pynnaert DVM R Van Beneden MS JM Ketelslegers MD PhD C Michaux DVM Phd M Balligand DVM PhD dipl ECVS-CA N Miserque DVM M Henroteaux DVM |
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| Institution: | aUniversity of Liège, Faculty of Veterinary Medicine, Department of Small Animal Clinical Sciences, B44, Sart Tilman, 4000 Liège, Belgium;bUniversity of Louvain, Unit of Diabetes and Nutrition, Avenue Hippocrate, 54, 1200 Brussels, Belgium;cUniversity of Liège, Faculty of Veterinary Medicine, Department of Genetics, B43, Sart Tilman, 4000 Liège, Belgium |
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| Abstract: | The aims of this study were to investigate (1) hormonal activation before and during dobutamine cardiac stress testing (DST) in a canine model of early left ventricular dysfunction (ELVD) induced by rapid right ventricular pacing (RRVP) and (2) the relationship between this hormonal profile and carnitine concentrations.Before the pacing period, the 6 dogs were assigned to 2 groups according their baseline total plasma carnitine concentration. A DST was performed on each dog before activation of the pacemaker and every 3 to 4 days during development of 3 progressive stages of ELVD (stages 1, 2 and 3). Plasma atrial natriuretic factor (ANF), angiotensin II (ANG II) and endothelin-1 (ET-1) levels were measured at the start and at the end of each DST. Effects of ELVD, DST and plasma carnitine concentration on these measurements were tested.The RRVP induced a significant increase of ANF and ANG II and a non significant trend toward increase of ET-1 in all dogs.Before the pacing period, ANF remained constant during the DST in dogs with normal total plasma carnitine concentration, while it significantly decreased in dogs with low total plasma carnitine concentration. Dobutamine stress testing induced a significant decrease in ANF in all dogs in ELVD. Dobutamine infusion induced a significant increase in ANG II in all dogs before as well as during the pacing period while ET-1 was unchanged.These results suggest that investigation of the hormonal profile before and after a dobutamine challenge might provide important diagnostic information in dogs with asymptomatic or mildly symptomatic cardiac dysfunction of different origins. |
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| Keywords: | Atrial natriuretic factor angiotensin-2 endothelin-1 carnitine dobutamine stress testing early left ventricular dysfunction |
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