| 锁阳中黄酮的抗氧化功能研究 |
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| 引用本文： | 郭豫,赵江燕,栾娜,张静,李迪.锁阳中黄酮的抗氧化功能研究[J].安徽农业科学,2011,39(32):19763-19764,19780. |
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| 作者姓名： | 郭豫 赵江燕 栾娜 张静 李迪 |
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| 作者单位： | 北京联合大学应用文理学院,北京,100191;北京联合大学应用文理学院,北京,100191;北京联合大学应用文理学院,北京,100191;北京联合大学应用文理学院,北京,100191;北京联合大学应用文理学院,北京,100191 |
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| 基金项目： | 北京市教委科技计划项目(KM200811417002) |
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| 摘 要： | 目的]探索锁阳黄酮对衰老小鼠机体抗氧化功能的影响。方法]采用9月龄雌性昆明小鼠,按体重随机分为4组。空白对照组每日灌胃无菌水;将制备的锁阳提取物干粉以无菌水制成溶液,低、中、高剂量组,按总黄酮计,分别按（BW）0.08、0.17、0.50 g/kg的量灌胃,连续灌胃54 d,按南京建成试剂盒说明分别测定超氧化物歧化酶（SOD）、丙二醛（MDA）、心肌脂褐质水平变化。结果]与空白对照组比较,各剂量组SOD活性均有明显的提高,低、高剂量组分别提高了18.6%和19.5%（P〈0.05）,中剂量组提高了22.7%,差异显著（P〈0.01）;各剂量组MDA含量均减少,中剂量组减少了15.0%,高剂量组减少了26.0%,差异显著（P〈0.01）;各剂量组心肌脂褐质含量均减少,中、高剂量组分别减少了11.2%和9.7%,差异显著（P〈0.05）。结论]超声提取的锁阳中的黄酮具有抗氧化功能。
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| 关 键 词： | 锁阳(HERBA CYNOMORII) 黄酮 抗氧化 |
Antioxidant Function of Flavonoids from Cynomorium songaricum Rupr |
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| Institution: | GUO Yu et al(College of Arts & Science,Beijing Union University,Beijing 100191) |
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| Abstract: | Objective] The aim was to explore the effects of flavonoids extracted from Cynomorium Songaricum Rupr.on the antioxidant function of aging mice.Method]9-month-old female Kunming mice were divided randomly into four groups.In control group,mice were given sterile water by gavage;in the low,medium and high dose groups,mice were given solutions of Cynomorium Songaricum Rupr.extract powder and sterile water by gavage for 54 d,with the flavonoids doses of BW 0.08,0.17,and 0.50 g/kg,respectively.Changes of SOD,MDA,and myocardial lipofuscin were determined according to the instructions of kits.Result] Compared with the control group,the activity of SOD increased significantly by 18.6%(P<0.05),19.5%(P<0.05) and 22.7%(P<0.01) in low,high and medium dose groups,respectively.MDA content reduced in three dose groups,which were 15.0%(P<0.05)in medium dose group and 26.0%(P<0.01)in high dose group.Myocardial lipofuscin content also decreased,in three dose groups,which were 11.2% and 9.7% in medium dose group and high dose group,respectively.Conclusion] Flavonoids extracted from Cynomorium Songaricum Rupr.by ultrasound had certain antioxidation activity. |
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| Keywords: | Cynomorium Flavonoids Antioxidation |
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