Comparative pharmacokinetics of sulfamethazine in plasma and parotid saliva of sheep |
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| Authors: | E Pulido F Meot H Sumano & R Boivin |
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| Institution: | Departement de Physiologie, École Nationale Vétérinaire de Lyon, 1, avenue Bourgelat, 1-B.P. 83 69280 Marcy L'Étoile, Lyon, France,;Department of Pharmacology, School of Veterinary Medicine, National Autonomous University of Mexico, Mexico City 04510, Mexico |
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| Abstract: | Salivary output in sheep is large enough to be considered a physiologic body fluid compartment. The hypothesis for this work was that pharmacokinetics of sulfamethazine in saliva was similar to that in plasma. A reliable technique was developed to measure parotid salivary output. Mean output of saliva was 3.18 ± 1.04 L from a single parotid gland per day with a mean flow of 2.21 ± 0.43 mL/min. Using concentrations of sulfamethazine in parotid saliva made it possible to calculate the total passage of sulfamethazine to parotid saliva, which was calculated to be 3.5% of the total dose. Pharmacokinetic variables obtained for sulfamethazine in plasma and in saliva were closely related ( AUC 1408 μg.h/mL and AUC 1484 μg.h/mL; V darea 0.434 L/kg and V d area 0.374 L/kg; t ½β 4.30 h and 3.46 h, respectively) and no substantial differences were observed. The convenience of using salivary concentrations of sulfamethazine for drug monitoring is discussed. |
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