A serological and molecular study on Francisella tularensis in rodents from Hamadan province,Western Iran |
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| Institution: | 1. Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran;2. National Reference Laboratory for Plague, Tularemia and Q Fever, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Kabudar Ahang, Hamadan, Iran;3. Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran;4. Food Hygiene and Public Health Department, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran;5. Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran;6. Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary;7. Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Budapest, Hungary;1. Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran;3. National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar-Ahang, Hamadan, Iran;4. Department of clinical sciences, Faculty of veterinary medicine, Islamic Azad University, Sanandaj Branch, Iran;5. Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran;1. Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;2. Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;3. Department of Biology and Control of Disease Vectors, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran;4. Zoonoses Research Center (ZRC), Ardabil University of Medical Sciences, Ardabil, Iran;1. Department of Pathology and Wildlife Diseases, National Veterinary Institute, Uppsala, Sweden;2. Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden;3. Department of Microbiology, National Veterinary Institute, Uppsala, Sweden;4. Swedish Defence Research Agency, Cementvägen 20, Umeå, Sweden;1. Praxis Dr. J. Borde, Gesundheitszentrum Oberkirch, Am Marktplatz 8, 77704 Oberkirch, Germany;2. Bundeswehr Institute of Microbiology, Neuherbergstraße 11, 80937 Munich, Germany;3. Department of Medicine II, Division of Infectious Diseases, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany |
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| Abstract: | Introduction and purposeTularemia is a zoonotic disease, the most important hosts of which are rodents. Endemic regions and reservoirs of F. tularensis are not well-researched areas in Iran. The present study aimed to study F. tularensis infection in the rodent populations of western Iran.Materials and methodsSamples were collected in different areas of Kabudar Ahang County in Hamadan province (west of Iran) from 2014 to 2017. Tularemia serological and molecular tests were conducted using the tube agglutination test and Real-time PCR method tracking the ISFtu2 gene. Positive serum samples were evaluated for cross-reactivity with brucellosis.ResultsA total of 433 rodents, collected from 33 localities, were included in the study. The most abundant species belonged to the Persian jird (Meriones persicus; 75.5%), and Libyan jird (Meriones libycus; 10.1%). Among the studied samples, three (0.74 %) were seropositive and five (1.15%) were PCR positive. Seropositive samples were two M. persicus and one M. libycus, and PCR positive rodents were four M. persicus and one M. vinogradovi. Tularemia seropositive samples showed no cross-reactivity with brucellosis.ConclusionGiven the presence of infection in rodents with tularemia agent in the studied area, it is crucial to elucidate the risks of rodent exposure to tularemia for physicians, health personnel and the general population. |
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| Keywords: | Tularemia Rodent Agglutination PCR Hamadan province |
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