Formulation of novel nano-encapsulated Newcastle disease vaccine tablets for vaccination of village chickens |
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| Authors: | Wambura Philemon N |
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| Institution: | (1) Department of Veterinary Microbiology and Parasitology, Sokoine University of Agriculture, P.O. Box 3019, Chuo Kikuu, Morogoro, Tanzania |
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| Abstract: | Formulation of nano-encapsulated vaccine tablet is a novel technique for the delivery of Newcastle disease (ND) vaccine to
village chickens. Vaccine tablets were prepared using gelatin, trehalose and casein as thermostabilisers and binders, respectively,
and each vaccine tablet contained a nominal oral dose of Newcastle disease virus (NDV) strain I-2 for a single chicken. These
ND vaccine tablets maintained a titre of 108.5 EID50/0.1 mL for 90 days at ambient room temperatures (25–34°C). When these vaccine tablets were given to village chickens, a single
oral administration of the vaccine produced protective antibody response (≥3.0 log2) against challenge with virulent NDV. The findings from the present study showed that, if the vaccine tablet formulation
technique is optimised, it will allow the delivery of the ND vaccine without depending on cold chains to rural areas in tropical
countries. |
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