Impairment of the peripheral lymphoid compartment in iron-deficient piglets |
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| Authors: | Svoboda M Drabek J Krejci J Rehakova Z Faldyna M |
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| Institution: | University of Veterinary and Pharmaceutical Sciences Clinic of Swine Diseases, Palackého 1-3, 612 42 Brno, Czech Republic. svobodama@vfu.cz |
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| Abstract: | The aim of this study was to investigate the effect of neonatal iron deficiency on immune functions in young piglets. While control piglets were not given any iron preparation until the age of 21 days, another group of piglets was given 200 mg of Fe(3+)-dextran i.m. on day 3. Red blood cell parameters in the former, iron-deficient group were characteristic of hypochromic anaemia. In addition, the total leucocyte count (P < 0.01), relative and absolute neutrophil count (P < 0.01) and absolute lymphocyte count (P < 0.05) in peripheral blood were found significantly lower in iron-deficient piglets than in their iron-supplemented counterparts. Lymphocyte activity as measured by in vitro lymphocyte transformation test was impaired in iron-deficient piglets. A statistically significant decrease in circulating B-lymphocyte numbers was found in non-supplemented animals. Iron deficiency apparently negatively influenced the immunocompetence in piglets. |
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