A Protective Effect of Vitamin E and Selenium in Ameliorating the Immunotoxicity of Malathion in Chicks |
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| Authors: | S Sodhi A Sharma R S Brar |
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| Institution: | (1) Department of Veterinary Pathology, Punjab Agricultural University, Ludhiana, India |
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| Abstract: | A study was conducted to determine whether a combination of vitamin E and selenium was able to counteract the immunosuppressive
effects of chronic toxicity of malathion in chicks. The chicks were divided into three groups. The first group received malathion
10 mg/kg body weight; the second group received the same dose of malathion but was supplemented with vitamin E and selenium
for 60 days; and the third group served as the control. The concentration of total immunoglobulins and circulatory immune
complexes decreased following the administration of malathion, whereas the supplementation of the diet with vitamin E and
selenium partially counteracted this effect. The histopathological changes in the bursa of Fabricius due to malathion were
consistent with these findings. Supplementation with vitamin E and selenium partially ameliorated the degenerative changes
in the bursa of Fabricius.
Sodhi, S., Sharma, A. and Brar, R.S., 2006. A protective effect of vitamin E and selenium in ameliorating the immunotoxicity
of malathion in chicks. Veterinary Research Communications, 30(8), 935–942 |
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| Keywords: | immunoglobulins circulatory immune complexes chicks bursa of Fabricius vitamin E selenium |
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