| 解毒除湿颗粒治疗大疱性类天疱疮湿热毒蕴证的临床观察 |
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| 作者姓名： | 冯瑞瑶 李小鹏 席建元 谢汶芳 彭丹 |
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| 作者单位： | 湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007 |
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| 摘 要： | 目的 评价解毒除湿颗粒治疗湿热毒蕴型大疱性类天疱疮（bullous pemphigoid，BP）的临床疗效，为BP提供一种新的、安全有效的治疗方法。方法 将60例BP患者随机分为治疗组与对照组各30例，治疗组予以解毒除湿颗粒联合醋酸泼尼松治疗，对照组予以醋酸泼尼松治疗，2个疗程（8周）结束后，比较两组患者治疗前后大疱性类天疱疮疾病面积指数评分（bullous pemphigoid disease area index，BPDAI）、各单项指标评分等改善情况及不良反应，以判定临床疗效及安全性。结果 治疗组总有效率82.76%，对照组总有效率58.62%，治疗组的疗效优于对照组（P<0.05）。治疗后治疗组及对照组皮肤评分、瘙痒程度、BPDAI及激素用量均较治疗前下降（P<0.05），且治疗组下降更显著（P<0.05）；但两组皮肤损害评分差异无统计学意义（P>0.05）。结论 解毒除湿颗粒联合醋酸泼尼松治疗湿热毒蕴型BP，能改善BPDAI，其中对于皮肤评分、瘙痒程度改善较明显，且激素减量优于单用醋酸泼尼松，未见明显毒副作用，安全可靠。
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| 关 键 词： | 大疱性类天疱疮 湿热毒蕴证 解毒除湿颗粒 面积指数评分 皮肤评分 瘙痒程度评分 |
| 收稿时间： | 2018/3/18 0:00:00 |
Clinical Efficacy of Jiedu Chushi Granule in Treating Bullous Pemphigoid with Dampness-Heat Toxin Amassment |
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| Authors: | FENG Ruiyao LI Xiaopeng XI Jianyuan XIE Wenfang and PENG Dan |
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| Institution: | The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China and The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China |
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| Abstract: | Objective To evaluate the clinical efficacy of Jiedu Chushi Granule in the treatment of bullous pemphigoid (BP) with dampness-heat toxin amassment, and to establish a new safe and effective treatment for BP.Methods Sixty patients with BP were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group received Jiedu Chushi Granule combined with prednisone acetate, and the control group was treated with prednisone acetate alone. After two courses of treatment (8 weeks), the improvements in Bullous Pemphigoid Disease Area Index (BPDAI) score and each index score as well as adverse reactions were compared between the two groups to assess the clinical efficacy and safety of the treatment.Results After treatment, the treatment group had a significantly higher overall response rate than the control group (82.76% vs 58.62%, P<0.05). Both groups showed significant reductions in skin score, pruritus score, BPDAI score, and dose of glucocorticoid after treatment (P<0.05), and the treatment group had significantly greater reductions (P<0.05). However, there was no significant difference in skin lesion score between the two groups (P>0.05).Conclusion Jiedu Chushi Granule combined with prednisone acetate can improve BPDAI score, as well as skin score and pruritus score in particular, in the treatment of BP with dampness-heat toxin amassment, and the combination therapy has a reduced dose of glucocorticoid compared with prednisone acetate alone. It is safe and reliable with no obvious toxic and side effects. |
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| Keywords: | bullous pemphigoid dampness-heat toxin amassment Jiedu Chushi Granule area index score skin score pruritus score |
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