| 不同剂量替米考星对塞北兔血压及心率的影响 |
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| 引用本文： | 张立永,利凯,李亚男,王杏.不同剂量替米考星对塞北兔血压及心率的影响[J].中国畜牧兽医,2010,37(7):184-185. |
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| 作者姓名： | 张立永 利凯 李亚男 王杏 |
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| 作者单位： | （河北北方学院动物科技学院， 宣化 075131） |
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| 摘 要： | 为探讨不同剂量替米考星对塞北兔血压和心率的影响,测定其变化规律,为临床合理用药提供理论依据。将24只健康塞北兔随机分为6组,替米考星添加量分别为对照组(0 mg/kg),Ⅰ组(20 mg/kg),Ⅱ组(40 mg/kg),Ⅲ组(60 mg/kg),Ⅳ组(80 mg/kg),Ⅴ组(100 mg/kg),测定用药后7 d的血压和心率。收缩压随着替米考星给药剂量的加大逐渐降低,舒张压逐渐升高,心率逐渐加快,且Ⅴ组家兔临床症状变化最显著。结果表明,依据本试验数据可以得出20 mg/kg的剂量对塞北兔是安全的;试验中100 mg/kg的最大剂量仍未致死试验兔,说明替米考星对塞北兔的安全范围较广。
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| 关 键 词： | 替米考星 血压 心率 塞北兔 |
Effects of Different Doses of Tilmicosin on Blood Pressure and Heart Beat in Saibei Rabbits |
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| ZHANG Li-yong,LI Kai,LI Ya-nan,WANG Xing.Effects of Different Doses of Tilmicosin on Blood Pressure and Heart Beat in Saibei Rabbits[J].China Animal Husbandry & Veterinary Medicine,2010,37(7):184-185. |
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| Authors: | ZHANG Li-yong LI Kai LI Ya-nan WANG Xing |
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| Institution: | (College of Animal Science, Hebei North University,Xuanhua 075131，China) |
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| Abstract: | In order to provide a theoretical basis for rational use drugs in clinic, the regular pattern of different doses of Tilmicosin on blood pressure and heart beat in Saibei rabbits were studied. 24 healthy Saibei rabbits were arranged into 6 groups randomly, the doses of Tilmicosin of the groups were control group（0 mg/kg），Ⅰgroup（20 mg/kg），Ⅱgroup（40 mg/kg），Ⅲ group (60 mg/kg)，Ⅳ group (80 mg/kg)，Ⅴgroup (100 mg/kg) respectively. The blood pressure and heart beat were measured after 7 d feeding with different doses of Tilmicosin. The systolic pressure was decreased by the increased of Tilmicosin,the diastolic pressure was increased gradually as well as the heart rate.The change of clinical symptoms of V gronp was the most significant. The results showed that the suitable dose of Tilmicosin was 20 mg/kg and the safety dose of Tilmicosin for Saibei Rabbit was 100 mg/kg. |
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| Keywords: | Tilmicosin blood pressure heart beat Saibei rabbit |
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