| Pharmacokinetics of Ivermectin in Salvelinus leucomaenis Following Two Ways of Administration |
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| 作者姓名： | 韩冰 杨洪波 王荻 卢彤岩 |
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| 作者单位： | [1]中国水产科学研究院黑龙江水产研究所,黑龙江哈尔滨150070 [2]上海海洋大学水产与生命学院,上海201306 |
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| 基金项目： | 公益性行业（农业）科研专项经费（201203085）;现代农业产业技术体系建设专项资金（CARS-46）. |
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| 摘 要： | 目的]研究伊维菌素在白点鲑体内的药动学。方法]对白点鲑以0．3mg／kg的剂量分别单次口灌和腹腔注射伊维菌素,采用高效液相色谱-紫外检测法（HPLC—UV）于给药后不同时间点连续进行采样检测,通过3p97软件分析药动学参数。结果]在2种给药方式下，伊维菌素在血浆、肌肉、肝和肾中的药时关系均符合一级吸收一室开放模型。口灌给药方式下，血浆中药动学参数为Tmax=4．503h、Cmax=0．252mg／L、t1/2ka=0．476h、t1/2ka=331．160h、AUC=121．524（mrdL）·h；腹腔注射给药方式下，血浆中药动学参数为Tmax=2．751h、Cmax=0．230mg／L、t1/2ka=0．306h、t1/2ka=153．868h、AUC=51．689（mg／L）·h。结论]两种给药方式下伊维菌素在白点鲑体内的药动学存在差异，腹腔注射给药比口灌给药吸收快。
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| 关 键 词： | 伊维菌素 白点鲑 药动学 |
Pharmacokinetics of Ivermectin in Salvelinus leucomaenis Following Two Ways of Administration |
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| Bing HAN,Hongbo YANG,Di WANG,Tongyan LU.Pharmacokinetics of Ivermectin in Salvelinus leucomaenis Following Two Ways of Administration[J].Agricultural Science ＆ Technology,2014(4):678-682,687. |
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| Authors: | Bing HAN Hongbo YANG Di WANG Tongyan LU |
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| Institution: | 1. Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin 150070, China; 2. College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China) |
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| Abstract: | Objective] This study was aimed to study the pharmacokinetics of iver- mectin in Salvelinus leucomaenis following a single oral administration or intraperi- toneal injection. Method] After a single oral administration or intraperitoneal injection of ivermectin with a dosage of 0.3 mg/kg body weight, samples were taken at dif- ferent time points and determined by high-performance liquid chromatography-ultravi- olet detection （HPLC-UV）. The pharmacokinetic parameters were calculated by 3p97 software. Result] The concentration-time relations of ivermectin in plasma, muscle, liver and kidney were well described by one-department open model with first-order absorption. After oral administration, the pharmacokinetic parameters in plasma were as follows： Tmax=4.503 h, Cmax=0.252mg/L, t1/2ka=0.476 h, t1/2ka=331.160 h, AUC=121.524 （mg/L） .h. After intraperitoneal injection, the pharmacokinetic parameters in plasma were as follows： Tmax=2.751 h, Cmax=0.230 mg/L, t1/2ka=0.306 h, t1/2ka=153.868 h, AUC= 51.689 （mg/L） .h. Conclusion] There were differences in the pharmacokinetics of ivermectin in Salvelinus leucomaenis between two different administration routes, and intraperitoneal injection led to more rapid absorption than oral administration. |
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| Keywords: | Ivermectin Salvelinus leucomaenis Pharmacokinetic |
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