Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12 |
| |
| Authors: | Wang Xiaochen Wu Yi-Chun Fadok Valerie A Lee Ming-Chia Gengyo-Ando Keiko Cheng Li-Chun Ledwich Duncan Hsu Pei-Ken Chen Jia-Yun Chou Bin-Kuan Henson Peter Mitani Shohei Xue Ding |
| |
| Institution: | Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. |
| |
| Abstract: | During apoptosis, phosphatidylserine, which is normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and has been suggested to act as an "eat-me" signal to trigger phagocytosis. It is unclear how phagocytes recognize phosphatidylserine. Recently, a putative phosphatidylserine receptor (PSR) was identified and proposed to mediate recognition of phosphatidylserine and phagocytosis. We report that psr-1, the Caenorhabditis elegans homolog of PSR, is important for cell corpse engulfment. In vitro PSR-1 binds preferentially phosphatidylserine or cells with exposed phosphatidylserine. In C. elegans, PSR-1 acts in the same cell corpse engulfment pathway mediated by intracellular signaling molecules CED-2 (homologous to the human CrkII protein), CED-5 (DOCK180), CED-10 (Rac GTPase), and CED-12 (ELMO), possibly through direct interaction with CED-5 and CED-12. Our findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
