| 8-羟基喹啉对草鱼急性毒性和遗传毒性的研究 |
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| 引用本文： | 南平,王君,潘春梅,郭变,豆小飞,常重杰.8-羟基喹啉对草鱼急性毒性和遗传毒性的研究[J].湖北农业科学,2012,51(7):1430-1432. |
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| 作者姓名： | 南平 王君 潘春梅 郭变 豆小飞 常重杰 |
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| 作者单位： | 河南师范大学生命科学学院,河南新乡,453007 |
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| 基金项目： | 国家自然科学基金项目，河南省杰出青年基金项目，河南省动物学重点学科资助项目 |
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| 摘 要： | 以8-羟基喹啉为诱变剂,研究了其对草鱼(Ctenopharyngodon idellus)的急性毒性和遗传毒性效应.急性毒性实验测得8-羟基喹啉对草鱼的24、48、96 h的LC50分别为32.30、26.93、20.95 mg/L,表现出较强的急性毒性,其安全浓度为11.62 mg/L.遗传毒性结果表明,处理组与空白对照组相比,微核率均达到显著或极显著差异水平(P＜0.05或P＜0.01),并且表现出明显的时间效应和剂量效应.因此,8-羟基喹啉在达到一定浓度和染毒时间以后对草鱼具有一定的遗传毒性,因而推测其大量使用可能对永生生物及生态环境具有一定的毒害作用.
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| 关 键 词： | 8-羟基喹啉 草鱼(Ctenopharyngodon idellus) 急性毒性 遗传毒性 微核 |
Study on the Acute Toxicity and Genetic Toxicity of 8-Hydroxyquinoline on Ctenopharyngodon idellus |
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| NAN Ping
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WANG Jun
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PAN Chun-mei
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GUO Bian
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DOU Xiao-fei
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CHANG Zhong-Jie.Study on the Acute Toxicity and Genetic Toxicity of 8-Hydroxyquinoline on Ctenopharyngodon idellus[J].Hubei Agricultural Sciences,2012,51(7):1430-1432. |
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| Authors: | NAN Ping WANG Jun PAN Chun-mei GUO Bian DOU Xiao-fei CHANG Zhong-Jie |
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| Institution: | (College of Life Sciences,Henan Normal University,Xinxiang 453007,Henan,China) |
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| Abstract: | The acute toxicity and genetic toxicity of 8-hydroxyquinoline on Ctenopharyngodon idellus red blood cells were studied.The LC50 in 24,48 and 96 h were 32.30,26.93 and 20.95 mg/L,respectively,showed relative high toxicity.The safety concentration of the 8-hydroxyquinoline for 96 h was 11.62 mg/L.Genetic toxicity assays showed that the micronucleus rates induced by 8-hydroxyquinoline in test groups were significantly different with the control group(P<0.05 or P<0.01),and it significantly correlated with the concentration and treatment time of 8-hydroxyquinoline.Therefore,a certain amount of 8-hydroxyquinoline or treatment time could lead to the genetic toxicity to Ctenopharyngodon idellu,suggested that the using of 8-hydroxyquinoline in industry may have the toxic effect to aquatic organisms and ecosystem. |
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| Keywords: | 8-hydroxyquinoline Ctenopharyngodon idellus acute toxicity genetic toxicity micronucleus |
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