| 肠道黏膜免疫研究进展 |
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| 引用本文： | 丁轲,余祖华,王天奇.肠道黏膜免疫研究进展[J].动物医学进展,2007,28(10):67-71. |
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| 作者姓名： | 丁轲 余祖华 王天奇 |
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| 作者单位： | 河南科技大学动物科技学院,河南洛阳,471003 |
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| 基金项目： | 河南科技大学校科研和教改项目 |
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| 摘 要： | 黏膜免疫是当前免疫学领域的研究热点,尤其是肠道黏膜免疫越来越被人们重视.近年来国内外学者分别探讨了肠道黏膜组织结构、肠道菌群及黏膜疫苗对黏膜免疫的作用及影响,研究表明,肠道黏膜组织结构中主要是M细胞、树突状细胞和巨噬细胞进行抗原摄取和转运,对起始黏膜免疫起着重要的作用.肠道菌群在免疫过程中主要是促进抗原的分泌和调节各种细胞因子的产生.合适的黏膜疫苗能够有效地激发黏膜免疫反应,具有方便、快捷、安全、有效、持续等优点.文章重点阐述了肠道菌群对黏膜免疫的影响及黏膜免疫的优点,并指出了制约黏膜免疫发展的关键因素、存在的问题及其发展前景.
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| 关 键 词： | 黏膜免疫 肠道菌群 黏膜疫苗 |
| 文章编号： | 1007-5038（2007）10-0067-05 |
| 修稿时间： | 2007-07-30 |
Progress on Gut Mucosal Immunization |
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| DING Ke,YU Zu-hua,WANG Tian-qi.Progress on Gut Mucosal Immunization[J].Progress In Veterinary Medicine,2007,28(10):67-71. |
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| Authors: | DING Ke YU Zu-hua WANG Tian-qi |
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| Institution: | College of Animal Science and Technology, Henan University of Science and Technology ,Luoyang , Henan,471003 ,China |
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| Abstract: | Mucosal immunization is one of the most important immune routines in immunology,especially gut mucosal immunization.In recent years,the effects on mucosal immunization of gut mucosal tissue structure,intestinal microflora and mucosal vaccines have been studied generally.The results showed that it was M cell,dendritic cell and macrophage to uptake and transport antigens in gut mucosal tissues,which was important to initiate the mucosal immunization.Intestinal microflora could promote the secretion of antigens and regulate the production of cytokines.Good mucosal vaccines could efficiently arouse mucosal immunization reaction,which was convenient,fast,safe,effective and persistent.Especially we explained the effects on mucosal immunization of intestinal microflora and the advantages of mucosal immunity,and analyzed the key restrict factors,the existing problems and prospects of mucosal immunity. |
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| Keywords: | mucosal immunization intestinal microflora mucosal vaccine |
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