| 乳铁蛋白肽的作用机制及其转基因研究进展 |
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| 引用本文： | 林松涛,张居农,王亮.乳铁蛋白肽的作用机制及其转基因研究进展[J].新疆农业科学,2008,45(3):498-503. |
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| 作者姓名： | 林松涛 张居农 王亮 |
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| 作者单位： | 石河子大学动,物科技学院,新疆石河子,832003;中科院新疆理化技术研究所,乌鲁木齐,830011;新疆金牛生物有限公司,乌鲁木齐,830026 |
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| 基金项目： | 新疆维吾尔自治区高新技术项目 |
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| 摘 要： | 近年来抗菌肽由于自身的优点已成为抗生素的替代品,并已成为研究与开发的热点 ,乳铁蛋白活性多肽(Lfcin)就是其中的一种,它是乳铁蛋白(LF)经胃蛋白酶在酸性条件下降解所产生的小肽,它构成了完整乳铁蛋白主要功能区的大部分,当它被降解下来后不仅仅保持了原来完整乳铁蛋白的活性甚至比原来完整乳铁蛋白的活性更强,因其具有广谱的抗细菌、抗病毒、抗真菌等多种独特的生物学活性而备受关注.对其结构、作用及作用机制、转基因研究这几方面的最新国内外研究动态进行综述.
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| 关 键 词： | 乳铁蛋白肽 乳铁蛋白 牛乳铁蛋白肽 人乳铁蛋白肽 结构 活性 表达量 |
| 文章编号： | 1001-4330(2008)03-0498-06 |
| 收稿时间： | 2008-03-25 |
| 修稿时间： | 2007年9月16日 |
Progress of Study on Action Mechanism and Transgene of Lactoferricin |
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| LIN Song-tao,ZHANG Ju-nong,WANG Liang.Progress of Study on Action Mechanism and Transgene of Lactoferricin[J].Xinjiang Agricultural Sciences,2008,45(3):498-503. |
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| Authors: | LIN Song-tao ZHANG Ju-nong WANG Liang |
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| Abstract: | In recent years,antibacteial petides have become desirable substitute of traditional antibiotic,and a focus of development and research .Lactoferricin(Lfcin) belongs to a kind of those antibacterial petides.The peptide lactoferricin(Lfcin) can be released from the lacto-ferrin(LF)through proteolysis by pepsin under acidic conditions.Lfcin encompasconsists of a large portion of the main functional domain of the intact protein,when it is released.It not only retains the activities of LF but is more active in many cases.Because it owns many such boil-ogical activities as Antibacterial activity,antifungal activity,antiviral activity and so on,it is being payed more attention by more researchers.Some newest developments of Lfcin on molecular structure,funcion,action mechanicsm and transgene at home and abroad were reviewed in this article. |
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| Keywords: | Lactoferrcin Lactoferrin Lfcin B Lfcin H structure activity express level |
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