Oral pharmacokinetics of acetaminophen to evaluate gastric emptying profiles
of Shiba goats |
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| Authors: | Mohamed ELBADAWY Kazuaki SASAKI Yuji MIYAZAKI Mohamed ABOUBAKR Waleed Fathy KHALIL Minoru SHIMODA |
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| Institution: | 1)Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183–8509, Japan;2)Pharmacology Department, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya, 13736, Egypt;3)Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt |
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| Abstract: | The pharmacokinetics of acetaminophen was investigated following oral dosing to Shiba
goats in order to evaluate the properties of gastric emptying. Acetaminophen was
intravenously and orally administered at 30 mg/kg body weight to goats using a crossover
design with a 3-week washout period. The stability of acetaminophen in rumen juice was
also assessed. Acetaminophen concentrations were measured by HPLC. Since acetaminophen was
stable in rumen juice for 24 hr, the extremely low bioavailability (16%) was attributed to
its hepatic extensive first-pass effect. The mean absorption time and absorption half-life
were unexpectedly short (4.93 and 3.35 hr, respectively), indicating its marked absorption
from the forestomach, which may have been due to its smaller molecular weight. Therefore,
acetaminophen was considered to be unsuitable for evaluating gastric emptying in Shiba
goats. |
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| Keywords: | acetaminophen gastric emptying goat oral absorption pharmacokinetics |
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