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| 纳米氧化铜对雏鸡全血和肝脏铜含量及肝脏铜蓝蛋白mRNA表达的影响 | |
| 引用本文： | 隋菲菲,朱连勤,朱风华,陈甫,王友令,孙金全.纳米氧化铜对雏鸡全血和肝脏铜含量及肝脏铜蓝蛋白mRNA表达的影响[J].中国兽医学报,2011,31(6). |
| 作者姓名： | 隋菲菲 朱连勤 朱风华 陈甫 王友令 孙金全 |
| 作者单位： | 1. 青岛农业大学,动物科技学院,山东青岛266109 2. 山东省农业科学院家禽研究所,山东济南,250100 3. 山东科技大学,山东青岛,266510 |
| 基金项目： | 国家自然科学基金资助项目(30871894) |
| 摘 要： | 选取1日龄SPF白莱航蛋用公雏63只,随机分为7组,1组受试鸡饲喂基础日粮;2～4组受试鸡分别饲喂以硫酸铜、氧化铜和纳米氧化铜的形式添加铜8mg/kg的饲料;5～7组受试鸡分别饲喂以硫酸铜、氧化铜和纳米氧化铜的形式添加铜175mg/kg的饲料。结果显示,日粮中添加铜8mg/kg或175mg/kg时,纳米氧化铜组受试鸡全血、肝脏铜含量显著高于氧化铜组、硫酸铜组和对照组(P<0.05);纳米氧化铜组受试鸡肝脏血浆铜蓝蛋白(CP)mRNA表达量显著高于硫酸铜组和氧化铜组(P<0.05)。试验至30d,日粮添加铜8mg/kg或175mg/kg时,纳米氧化铜组受试鸡血浆CP活性显著高于硫酸铜组和氧化铜组(P<0.05)。表明纳米氧化铜通过提高脏器组织铜沉积、上调铜酶或铜蛋白的基因表达来提高铜酶活性,从而发挥其生物学作用。 |
| 关 键 词： | 雏鸡 纳米氧化铜 铜蓝蛋白 铜 |
Effects of nano-CuO on contents of copper in blood and liver,the CP mRNA expression of liver in chickens |
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| SUI Fei-fei,ZHU Lian-qin,ZHU Feng-hua,CHEN Fu,WANG You-ling,SUN Jin-quan.Effects of nano-CuO on contents of copper in blood and liver,the CP mRNA expression of liver in chickens[J].Chinese Journal of Veterinary Science,2011,31(6). | |
| Authors: | SUI Fei-fei ZHU Lian-qin ZHU Feng-hua CHEN Fu WANG You-ling SUN Jin-quan |
| Institution: | SUI Fei-fei1,ZHU Lian-qin1,ZHU Feng-hua1,CHEN Fu1,WANG You-ling2,SUN Jin-quan3(1.College of Animal Science and Veterinary Medicine,Qingdao Agricultural University,Qingdao,Shandong 266109,China,2.Institute of Poultry Sciences,SAAS,Jinan 250100,3.Shandong Science and Technology University,Shandong 266510,China) |
| Abstract: | In order to discover the biological effect of nano-CuO in the chickens,the experiment was conducted to determine effects of CuSO4,CuO and nano-CuO on the contents of copper in blood and liver,the CP activity of plasma,and the CP mRNA expression of liver in SPF chickens.One-day-old White Leghorn SPF chickens were divided into 7 groups of 9 each randomly.The group 1 chickens were fed the basal diet.The chickens in group 2,3 and 4 were fed the diets with 8 mg/kg Cu in the form of CuSO4,CuO and nano-CuO,respect... |
| Keywords: | chicken nano-CuO ceruloplasmin copper |
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