| 伊维菌素对鲫血液成分影响的初步研究 |
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| 引用本文： | 彭章晓,江敏,吴昊,何琳,杨李.伊维菌素对鲫血液成分影响的初步研究[J].淡水渔业,2012,42(1):93-96. |
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| 作者姓名： | 彭章晓 江敏 吴昊 何琳 杨李 |
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| 作者单位： | 1. 上海海洋大学水产与生命学院,上海201306;上海交通大学药学院,上海200240
2. 上海海洋大学水产与生命学院,上海,201306 |
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| 基金项目： | 上海市教委理科重点项目，上海市教委重点学科建设项目，上海海洋大学博士启动基金 |
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| 摘 要： | 采用三种给药剂量(3.0、1.0、0.4 mg/kg)研究伊维菌素对鲫(Carassius auratus)血液指标的影响,结果显示:各实验组鲫血液中红细胞(RBC)、白细胞(WBC)、红细胞压积(HCT)、血红蛋白(HGB)与对照组间均无显著性差异;但血小板(PLT)指标则显著高于对照组,且在给药后8～16 h快速上升、24 h后开始下降,波动幅度亦显著高于对照组。三种口灌剂量对鲫血液中钙离子(Ca2+)、总胆红素(Tbil)、碱性磷酸酶(ALP)、丙氨酸氨基转移酶(ALT)和白蛋白(ALB)含量均无明显影响;而3.0、1.0 mg/kg的口灌剂量组鲫血液中总血清蛋白(TP)含量较对照组有下降,且剂量越大影响越大,而0.4 mg/kg组TP含量变化不大。随着剂量的增大,鲫体色逐渐变深,食欲减退、身体失衡,3.0 mg/kg组的鲫解剖后显示肾脏出血迹象。
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| 关 键 词： | 鲫(Carassius auratus) 伊维菌素 血液成分 |
Preliminary study on the influence of ivermectin on blood component of Carassius auratus |
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| PENG Zhang-xiao
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JIANG Min
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WU Hao
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HE Lin
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YANG Li.Preliminary study on the influence of ivermectin on blood component of Carassius auratus[J].Freshwater Fisheries,2012,42(1):93-96. |
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| Authors: | PENG Zhang-xiao JIANG Min WU Hao HE Lin YANG Li |
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| Institution: | 1(1.College of Fisheries and Life Science,Shanghai Ocean University,shanghai 201306,China; 2.School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China) |
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| Abstract: | The influence of ivermectin on Carassius auratus blood component was studied after oral administration at ivermectin doses of 3.0,1.0 and 0.4 mg/kg.The results showed that RBC,WBC,HCT and HGB in Carassius auratus blood had no obvious difference among control group and treatment groups.The contents of PLT in treated fish were obviously higher than those in untreated fish.The contents of PLT increased quickly at 8~16 h after administration,and began to decrease at 24 h,and the fluctuation was greater than that in control group.The contents of Ca2+,Tbil,ALP,ALT and ALB didn’t be affected by ivermectin.While the contents of TP in blood of fish administrated with 3.0 or 1.0 mg/kg ivermectin were lower than untreated fish,and with the increase of dose,the greater the influence was,while 0.4 mg/kg ivermectin didn’t affect the content of TP obviously.Some adverse reactions were observed including darkened color,loss of appetite,and balance in treated fishes with the increasing dose.There was external hemorrhage in kidneys when the fish in group of 3.0 mg/kg was dissected. |
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| Keywords: | Carassius auratus ivermectin blood component |
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