Mutagenic activity ofMintostachys mollis in AHH1 lymphoblast cells |
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| Authors: | Guy Carvajal William Thilly |
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| Institution: | (1) Genetic Toxicology Group, Department of Nutrition and Food Science, Massachusets Institute of Technology, 02139 Cambridge, MA, USA;(2) Present address: Laboratorio de Microbiologia, ITP Research Centre, P.O. Box 0360, Callao, Peru |
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| Abstract: | Cultured AHH1 human lymphoblast cells were exposed to an extract ofMintostachys mollis, which is used as a medicinal plant and preservative in Peru, to detect its mutagenic activity. A three-day exposure to concentrations of 1, 10, 30 and 50 µg/ml resulted in induced mutant fraction of 1.02, 1.79, 2.21 and 3.80 mutations per million cells per day, expressed as 6-Thioguanine resistance. A concentration of 10µg/ml induced 11.9 times the spontaneous mutant fraction of AHH1 cells. The doubling dose determined to be 838 ng/ml. A concentration of 30 µg/ml of this compound resembled the induced rate of 1 µM benzo ( ) pryene. |
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| Keywords: | Mintostachys mollis mints mutagenity plant extract lymphoblast cells |
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