|
|||||
|
|
| T、B淋巴细胞功能对流行性牛白血病发生发展的影响 | |
| 引用本文： | 王选年,潘耀谦,康晓迪,张改平.T、B淋巴细胞功能对流行性牛白血病发生发展的影响[J].动物医学进展,2001,22(1):5-11. |
| 作者姓名： | 王选年 潘耀谦 康晓迪 张改平 |
| 作者单位： | 1. 河南职业技术师范学院, 2. 解放军军需大学, 3. 河南百奥生物技术有限公司, 4. 河南省农业科学院, |
| 摘 要： | 本文回顾了T、B淋巴细胞功能与牛白血病发生发展的相关性。阐明了感染BLV牛B细胞淋巴瘤细胞除了来源于Bla(CD5^ CD11b^ )细胞，也可来源于B1b(CD5^-CD11b^ )及常规B2（CD5^-CD11b^-)细胞。探讨了T细胞功能对牛白血病的发生发展的影响，指出IL－12表达下降和IL－10表达增加可能导致了B细胞淋巴肉瘤的形成，Ⅰ型和Ⅱ型细胞因子的不平衡引起了BLV的发展。同时讨论了B－T细胞的相互作用在BLV感染时疾病阶段性发展过程中的作用。 |
| 关 键 词： | 牛白血病 B淋巴细胞亚群 细胞因子 B－T细胞相互作用 |
| 文章编号： | 1007-5038(2001)01-0005-07 |
The Relationship Between the Function of T、B Lymphocytes and the Pathogenesis of Enzootic Bovine Leukosis |
|
| WANG Xuan-nian,PAN Yao-qian,KANG Xia-di,Zhang Gai-ping.The Relationship Between the Function of T、B Lymphocytes and the Pathogenesis of Enzootic Bovine Leukosis[J].Progress In Veterinary Medicine,2001,22(1):5-11. | |
| Authors: | WANG Xuan-nian PAN Yao-qian KANG Xia-di Zhang Gai-ping |
| Institution: | WANG Xuan nian 1,PAN Yao qian 2,KANG Xia di 3,ZHANG Gai ping 4 |
| Abstract: | This review focuses on the relationship between the function of T、B lymp hocytes and the pathogenesis of Enzootic Bovine Leukosis. In BLV infection anima l, the phenotypes of B-cells lymphoma can be derived from B1a(CD5+CD11 b+), B1b(C D5－CD11b+) and conventional B2(CD5－CD11b－)cells. Co mbined with previous findi ngs the data suggests that the decrease of IL-12 and the increase of IL-10 res ult in the formation of B-cell lymphosarcoma, and the imbalance of phenotype Ⅰ and Ⅱ cytokines causes the progression of Bovine Leukemia. M eanwhile, the interaction of B and T cells could contribute to the polyclonal ac tivation and proliferation of B lymphocytes in BLV infectea animals. |
| Keywords: | Enzootic Bovine Leukosis B lymphocytes subset Cytokine B T cell interaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |