| 白藜芦醇对动脉粥样硬化大鼠核转录因子NF-кB的影响 |
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| 引用本文： | 屈琴,焦金菊,王长辉,王青青,杜迎祥.白藜芦醇对动脉粥样硬化大鼠核转录因子NF-кB的影响[J].安徽农业科学,2010,38(4):1671-1672,1694. |
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| 作者姓名： | 屈琴 焦金菊 王长辉 王青青 杜迎祥 |
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| 作者单位： | 辽宁医学院生理学教研室,辽宁锦州,121000 |
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| 摘 要： | 目的]研究白藜芦醇（Res）对动脉粥样硬化（AS）大鼠血脂水平和NF-κB的影响,探讨抗AS的部分机制。方法]制成AS大鼠模型后,设4个组：①模型对照组（高脂饲料）;②低剂量给药组高脂饲料＋Res30mg/（kg·d）];③中剂量给药组高脂饲料＋Res60mg/（kg·d）];④高剂量给药组高脂饲料＋Res120mg/（kg·d）],连续灌胃给药5周后,测定各组血脂和血管壁组织NF-кB阳性细胞表达率。结果]各给药组TG、TC和LDL-C均较对照组有不同程度的降低,HDL-C较对照组有所升高;免疫组化和蛋白印迹分析均显示各给药组NF-кB阳性细胞表达率明显低于对照组。结论]白藜芦醇可调节AS大鼠血脂,降低AS大鼠主动脉壁NF-κB的表达,从而抑制AS的形成。
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| 关 键 词： | 白藜芦醇 动脉粥样硬化 核转录因子NF-κB |
Influence of Resveratrol on Expression of Nuclear Factor-κB in Aorta of Rat with Atherosclerosis |
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| QU Qin et al.Influence of Resveratrol on Expression of Nuclear Factor-κB in Aorta of Rat with Atherosclerosis[J].Journal of Anhui Agricultural Sciences,2010,38(4):1671-1672,1694. |
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| Authors: | QU Qin |
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| Institution: | Physiology Department;Liaoning Medical University;Jinzhou;Liaoning 121000 |
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| Abstract: | Objective] The research aimed to study the effect of resveratrol(Res) on the lipid levels of atherosclerosis (AS) rats and NF-κB, and to explore its mechanism of anti-AS. Method] AS rats were made. Four groups were as follows: ①control (high fat diet), ② low-dose treatment high fat diet and Res 30 mg/(kg·d)], ③medium-dose treatment high fat diet and Res 60 mg/(kg·d)], ④high-dose treatment high fat diet and Res 120 mg/(kg·d)].The rats were kept gavaging for 5 weeks, and the lipid concentration of each group and NF-κB expression positive cell rate of vascular wall tissue were determined. Result] TG, TC and LDL-C of treatment were all lower than those of the control to varying degrees, and HDL-C was higher than that of the control. The consequence of immunohistochemistry and Western Blotting showed that NF-кB positive cells rate of each treatment was significantly lower than that of the control. Conclusion] Resveratrol could modulate serum lipids of AS rats, reduce NF-κB expression in aorta wall of AS rats, thus inhibit the formation of AS. |
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| Keywords: | Resveratrol Atherosclerosis |
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