Trichinella: differing effects of antigens from encapsulated and non-encapsulated species on in vitro nitric oxide production |
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| Authors: | Andrade M Amparo Siles-Lucas Mar López-Abán Julio Nogal-Ruiz Juan José Pérez-Arellano José Luis Martínez-Fernández Antonio R Muro Antonio |
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| Institution: | Laboratorio de Inmunología Parasitaria y Molecular, CISET, Facultad de Farmacia, Universidad de Salamanca, Avda. Campo Charro, s/n 37007, Salamanca, Spain. |
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| Abstract: | Trichinellosis is a cosmopolitan zoonotic disease affecting a wide variety of animals, including man. Non-encapsulated and encapsulated species diverge with respect to their developmental strategies. Little is known at the molecular level about parasite-derived mediators responsible for host muscle cell transformation occurring during trichinellosis. In this context, host-parasite relationships in Trichinella-infected animals could be related to different host-immune and cell mediators, e.g. nitric oxide (NO). Here, we investigate the stimulatory/inhibitory role of L1 antigens from four encapsulated (T. spiralis, T. britovi, T. nelsoni and T. nativa) and one non-encapsulated (T. pseudospiralis) Trichinella species on NO production from rat macrophages in vitro. Our results demonstrate that encapsulated and non-encapsulated Trichinella species differ in their capacity to stimulate the secretion of NO from host macrophages. Biological significance of these differences should be further assessed in the available experimental models. |
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| Keywords: | Trichinella sp Nitric oxide Macrophages |
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