Abnormally modified tau and hypoxic-ischemic brain damage |
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| Authors: | XIAO Jie LI Fan |
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| Institution: | Department of Pathology and Pathophysiology, Basic Medical College, Kunming Medical University, Kunming 650500, China |
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| Abstract: | Tau is the most abundant microtubule-associated protein in the brain. If tau protein lost the normal function, the toxic effect should be showed and plays an important role in various central nervous system lesions. Hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality in the neonatal period and it is mainly characterized by neurological deficits such as cognitive limitations. However, the mechanism still needs further study, and the underlying relationship between tau protein and HIE lacks direct evidence. Some recent clinical study reported that tau protein expression elevated in the serum of asphyxia children and had a high correlation with behavior deficient. In this review, we focus on 3 key points to provide new insights to understand the tau protein-related pathogenesis of HIE as followed: (1) tau protein and its phosphorylation change during central nervous system development; (2) comparison of tau protein expression in developing brain and adult brain under some neurological disorders; (3) potential pathological change of tau in HIE related pathological conditions, such as dysmyelination, inflammation response and glutamate metabolism. |
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| Keywords: | Protein tau Hypoxic-ischemic brain damage Dysmyelination Glutamate metabolism |
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