Effects of atorvastatin on release of endothelial microparticles and myocardial apoptosis in rats with acute myocardial infarction |
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| Authors: | LI Qiang GUO Zhuang-bo WU Guang-ying LI Chao-xia ZHONG Zhi-yong |
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| Institution: | 1. Department of Emergency, Guangzhou Red Cross Hospital, the Fourth Affiliated Hospital, School of Medicine, Jinan University, Guangzhou 510220, China;
2. Clinical Laboratory, Guangzhou Red Cross Hospital, the Fourth Affiliated Hospital, School of Medicine, Jinan University, Guangzhou 510220, China;
3. Medical Laboratory Animal Center of Guangdong Province, Foshan 528248, China |
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| Abstract: | AIM: To investigate the effect of atorvastatin(AT) on the release of endothelial microparticles(EMP) and myocardial apoptosis in the rats with myocardial infarction. METHODS: SD male rats(n=24) were randomly divided into 3 groups:sham operation(sham) group, myocardial infarction(MI) group and MI+AT group. The rat model of acute myocardial infarction was prepared by coronary artery ligation. At 2 h and 24 h after modeling, the peripheral blood was collected to detect creatine kinase-MB(CK-MB) and cardiac troponin T(cTnT). The circulating levels of EMP were measured by flow cytometry. The myocardial apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) assay. RESULTS: At 2 h after modeling, the level of CK-MB was significantly increased in MI group compared with sham group, and the level of EMP and the myocardial apoptotic rate were significantly increased in MI group and MI+AT group compared with sham group. At 24 h after modeling, the level of EMP was significantly increased in MI group compared with sham group. The levels of CK-MB, cTnT, EMP and the myocardial apoptotic rate were significantly decreased in MI+AT group compared with MI group. Moreover, the level of CK-MB in MI group was significantly increased at 24 h compared with that at 2 h after modeling. The levels of CK-MB, cTnT and EMP were significantly decreased in MI+AT group at 24 h compared with those at 2 h after modeling. CONCLUSION: Ator-vastatin may reduce the level of EMP and the myocardial apoptotic rate in the rats with acute myocardial infarction, indicating that atorvastatin plays a role in protecting endothelium. |
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| Keywords: | Acute myocardial infarction Atorvastatin Endothelial microparticles Cardiomyocyte apoptosis |
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