Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5 |
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| Authors: | Lederman Michael M Veazey Ronald S Offord Robin Mosier Donald E Dufour Jason Mefford Megan Piatak Michael Lifson Jeffrey D Salkowitz Janelle R Rodriguez Benigno Blauvelt Andrew Hartley Oliver |
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| Institution: | Department of Medicine, Case Western Reserve University, University Hospitals, 2061 Cornell Road, Cleveland, OH 44106, USA. |
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| Abstract: | Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus-modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention. |
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