| 2-辛亚砜-5,8-二甲氧基-1,4萘醌通过ROS/Akt通路诱导HepG2细胞凋亡 |
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| 引用本文： | 邱美玉,刘军,申贵男,崔玉东,韩英浩.2-辛亚砜-5,8-二甲氧基-1,4萘醌通过ROS/Akt通路诱导HepG2细胞凋亡[J].黑龙江八一农垦大学学报,2016(5):81-86. |
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| 作者姓名： | 邱美玉 刘军 申贵男 崔玉东 韩英浩 |
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| 作者单位： | 黑龙江八一农垦大学生命科学技术学院,大庆,163319 |
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| 基金项目： | 黑龙江八一农垦大学校科研启动计划项目(XYB2012-12)。 |
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| 摘 要： | 为研究修饰后的萘醌类衍生物对人肝癌细胞株HepG2诱导细胞凋亡作用及其机制。采用MTT、流式和Western blot方法观察2-辛亚砜-5,8-二甲氧基-1,4萘醌对人肝癌细胞的生长作用。结果表明:2-辛亚砜-5,8-二甲氧基-1,4萘醌可通过促进早期ROS水平升高,抑制Akt的磷酸化水平,并选择性地激活p38,ERK信号通路,从而抑制肝癌细胞株HepG2细胞的增殖并诱导其发生凋亡。
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| 关 键 词： | 萘醌类衍生物 HepG2 增殖抑制 活性氧 |
2-(octane-1-sulfinyl)-5,8-Dimethoxy-1,4-Naphthoquinone Induce HepG2 Apoptosis through ROS/Akt and MAPKs Pathway |
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| Abstract: | To investigate the effects of modified naphthoquinone derivatives on apoptosis in hepatocellular carcinoma HepG2 cells and its underlying mechanism. The effect of 2-(octane-1-sulfinyl)-5,8-Dimethoxy-1,4-Naphthoquinone on the growth of human hepatocellular carcinoma cells was observed by MTT,flow and Western blot method.The results showed that 2-(octane-1-sulfinyl)-5,8-Dimethoxy-1,4-Naphthoquinone could elevate ROS level,inhibit phosphorylation of Akt,selectively activate p38 and ERK signaling pathway,thus inhibite proliferation and induce apoptosis of HepG2 cell. |
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| Keywords: | naphthoquinone derivatives HepG2 proliferation inhibition ROS |
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