Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose,milking frequency and udder health |
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| Authors: | Baljinder Kumar Bansal Navdeep S Bajwa S S Randhawa Rakesh Ranjan P S Dhaliwal |
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| Institution: | (1) Department of Clinical Veterinary Medicine, Ethics and Jurisprudence, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141 004, Punjab, India |
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| Abstract: | Elimination of erythromycin in milk following intramammary therapy of specific mastitis in cows was studied. Five cows received
therapy in one quarter (G1), and eight in two quarters with five milked twice (G2) and three thrice a day (G3). Dose infused
was 300 mg/quarter 12 h × 5 times. The drug concentrations in milk were determined using microbial assay technique with Micrococcus luteus as the test organism. Considerable variations occurred in the excretion of drug; levels for treated quarters being 8.25 to
37.61 μg/ml at first milking that declined rapidly at 24 h and no drug activity was observed beyond 36 h post treatment. In
total, about 6–25% of the last infused dose appeared in the milk. Drug crossed to 1/15 quarter (G1), 6/10 quarters (G2) and
all the six untreated quarters (G3). Crossover levels were significantly higher in mastitic quarters and for G3 cows, but
duration of excretion remained same in all cases. It seems that crossover of erythromycin to untreated quarters is related
to the udder health and dose infused. |
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