| 泰妙菌素的体外抑菌活性与一般毒性研究 |
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| 引用本文： | 王丽平,江善祥,史晓丽,万荣峰,郭永刚,冯秀娟.泰妙菌素的体外抑菌活性与一般毒性研究[J].畜牧与兽医,2004,36(6):4-6. |
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| 作者姓名： | 王丽平 江善祥 史晓丽 万荣峰 郭永刚 冯秀娟 |
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| 作者单位： | 南京农业大学动物医学院,江苏,南京,210095 |
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| 摘 要： | 采用二倍稀释法、改良寇式法和蓄积系数法测定了泰妙菌素的体外抑菌活性、急性毒性和蓄积毒性。体外抑菌试验结果显示,泰妙菌素对猪、鸡支原体、猪链球菌、金黄色葡萄球菌的最小抑菌浓度分别为0 015、0 125、0 5ug/mL,呈现较好的杀菌效果,且较磷酸泰乐菌素效果好;而对大肠杆菌、禽巴氏杆菌效果较差。一般毒性试验结果显示,泰妙菌素对小鼠、鸡的经口LD50分别为1 58g/kg和2 19g/kg。按国际急性毒性分级标准可判断为实际无毒,蓄积系数K>5,为弱蓄积性,且小鼠对其不具有耐受性。
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| 关 键 词： | 泰妙菌素 最小抑菌浓度 LD_(50) 蓄积系数 耐受性 |
| 文章编号： | 0529-5130(2004)06-0004-03 |
| 修稿时间： | 2003年11月20 |
Tamulin:the antimicrobial susceptibility in virtro and the common toxicity in virtro |
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| WANG Li-ping,JIANG Shan-xiang,SHI Xiao-li.WAN Rong-feng,GUO Yong-gang,FENG Xiu-juan..Tamulin:the antimicrobial susceptibility in virtro and the common toxicity in virtro[J].Animal Husbandry & Veterinary Medicine,2004,36(6):4-6. |
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| Authors: | WANG Li-ping JIANG Shan-xiang SHI Xiao-liWAN Rong-feng GUO Yong-gang FENG Xiu-juan |
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| Abstract: | The in vitro antimicrobial susceptibility, acute toxic effect and accumulate toxic effect of taimulin were detected by the two fold dilution susceptibility test, modified Kaber method and accumulation coefficient method, respectively. The results showed that taimulin had good antibacteribial effect against Mycoplasma, S. suis and S. aureus and the MIC were 0.015,0.125 and 0.5 g/mL, respectively. But the antibacterial effect against E. coli and P. avium were poor. The LD(50) of taimulin were 1.58 g/kg to mice and 2.19 g/kg to chicken, which was not toxic according to the international standard. The accumulation co-efficient was more than 5 showing a weak accumulation and the mice had no resistance to taimulin.. |
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| Keywords: | LD50 |
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