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| 淫蜂佐剂对实验动物NK细胞活性的影响 | |
| 引用本文： | 刘家国,张宝康,胡元亮,宋大鲁,步志亮,叶洪,徐树培,谢军,邓茂刚.淫蜂佐剂对实验动物NK细胞活性的影响[J].动物医学进展,2001,22(2):74-76. |
| 作者姓名： | 刘家国 张宝康 胡元亮 宋大鲁 步志亮 叶洪 徐树培 谢军 邓茂刚 |
| 作者单位： | 1. 南京农业大学动物医学院, 2. 成都机械厂 3. 四川省畜牧兽医研究所 4. 成都凤凰山奶牛场 5. 江苏省畜牧兽医学院 |
| 基金项目： | 国家自然科学基金资助项目! (392 70 5 2 2 ) |
| 摘 要： | 用微量乳酸脱氢酶（LDH）释放法分别观察了淫羊藿－蜂胶佐剂（以下简称“淫蜂佐剂”）对小鼠脾脏和雏鸡外周血中自然杀伤细胞（NK细胞）活性的影响。结果：小鼠NK细胞活性在淫蜂佐剂（Ⅰ）组、生理盐水对照（Ⅳ）组、淫蜂＋环磷酰胺（Ⅱ）组和环磷酰胺（Ⅲ）组的上述各组间差异显著或极显著（P＜0．05或P＜0．01）（Ⅱ组和Ⅳ组间差异不显著，P＞0．05），这种差异在4周龄小鼠较8周龄小鼠更为明显。雏鸡NK细胞活性，35日龄时，注射淫蜂佐剂雏鸡极显著高于注射生理盐水雏鸡，0．4mL／羽组明显高于0．2mL/ 羽组。上述结果表明，淫蜂佐剂能提高实验动物NK细胞活性，并拮抗环磷酰胺对NK细胞活性的抑制作用。淫蜂佐剂的这种作用在适龄的幼年动物中表现更为显著，并存在一定的量效关系。 |
| 关 键 词： | 淫蜂佐剂 小鼠 鸡 NK细胞活性 免疫功能 |
| 文章编号： | 1007-5038(2001)02-0074-03 |
| 修稿时间： | 2000年12月29 |
Effect of Epimedium-Propolis Adjuvant on Natural Killer Lymphocyte Activity |
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| LIU Jia guo,HU Yuan liang,ZHANG Bao kang,SON Da lu,BU Zhi liang.Effect of Epimedium-Propolis Adjuvant on Natural Killer Lymphocyte Activity[J].Progress In Veterinary Medicine,2001,22(2):74-76. | |
| Authors: | LIU Jia guo HU Yuan liang ZHANG Bao kang SON Da lu BU Zhi liang |
| Abstract: | The effect of Epimedium-Propolis adjuvant on the NK cell activity of mousy splenic and chicken’s peripheral blood was tested respectively by microassay LDH release.The results were as follows:The NK cell activity of mousy splenic decreased with the sequence as follows:group Ⅰ (treated by EPA only) group Ⅳ (treated with physidogical saline solution),group Ⅱ (treated by EPA with Cyclophosphamidum),group Ⅲ (treated with Cyelophosphamidum only).The difference among these group atoresaid was remarkable(P＜0.05 orP＜0.01) but between the group Ⅱ and Ⅳ no significant(P＞0.05).The difference in the 4-week-old mice was superior to that in the 8-week-old mice.The NK cell activity of chicken in those groups treated with EPA was significantly superior to those treated by physiological saline only on the 35th day and ,moreover,the activity in those treated by 0.4ml EPA was higher than those by 0.2ml EPA(P＜0.05).These results indicated that the EPA could not only enhance the NK cell activity of experimental animals,but also resist the immunosuppression by the Cyelophosphamidum,especially to the juvenile animal.And there was some kinds of relation between the effect and the dosage of the EPA. |
| Keywords: | EP Aduvant mice chicken NK cell activity |
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