Taurine synthesis via the cysteic acid pathway: effect of dietary cysteic acid on growth,body taurine content,and gene expression of taurine-synthesizing enzymes,growth hormone,and insulin-like growth factor 1 in Japanese flounder Paralichthys olivaceus |
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Authors: | Nakamura Kohei Gonzales-Plasus Marina Mojena Ushigusa-Ito Tomoko Masuda Reiji Kabeya Naoki Kondo Hidehiro Hirono Ikuo Satoh Shuichi Haga Yutaka |
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Institution: | 1.Course of Applied Marine Biosciences, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan, Minato, 4-5-7, Tokyo, 108-8477, Japan ;2.Western Philippines University, Rafols Road, Pajara, Barangay Santa Monica, 5300, Puerto Princesa City, Palawan, Republic of the Philippines ;3.Maizuru Fisheries Research Station, Field Science Education and Research Center, Kyoto University, Nagahama, Maizuru, Kyoto, 625-0086, Japan ;4.Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Konan, Minato, 4-5-7, Tokyo, 108-8477, Japan ; |
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Abstract: | Here, we investigated the effect of dietary cysteic acid on the growth performance, sulfur amino acid content, and gene expression levels of taurine-synthesizing enzymes, growth hormone (GH), and insulin-like growth factor 1 (IGF-1) in Japanese flounder Paralichthys olivaceus. Juvenile flounder (0.9 g) were fed one of four diets for 30 days: with 0.25, 0.5, or 1.0% cysteic acid (C0.25, C0.5, C1.0) supplementation and without supplementation (control). Fish in the C0.25 and C0.5 groups showed significantly better growth than those in the control group (P?<?0.05). Body taurine content was significantly higher in C0.25, C0.5, and C1.0 fish than in control fish (P?<?0.05). Although there was no significant difference in gene expression levels of taurine-synthesizing enzymes and GH among groups (P?>?0.05), the expression level of IGF-1 in C1.0 fish was significantly higher than that in controls (P?<?0.05). Our results suggest that Japanese flounder can synthesize taurine from cysteic acid, that dietary supplementation with up to 0.5% cysteic acid promotes fish growth, and that dietary cysteic acid can affect the GH-IGF axis in Japanese flounder. These findings thus highlight the importance of the cysteic acid pathway for taurine synthesis and growth in this species. |
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