| 饲粮中添加泛酸对生长獭兔肝脏脂肪代谢的影响 |
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| 引用本文： | 刘磊,赵楠,张斌,李福昌.饲粮中添加泛酸对生长獭兔肝脏脂肪代谢的影响[J].动物营养学报,2017,29(6). |
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| 作者姓名： | 刘磊 赵楠 张斌 李福昌 |
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| 作者单位： | 山东农业大学动物科技学院,泰安,271018 |
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| 基金项目： | 中国博士后科学基金项目，山东农业大学青年科技创新基金项目，山东农业大学博士后科学基金项目，现代农业产业技术体系建设专项 |
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| 摘 要： | 本试验旨在研究饲粮中添加泛酸对生长獭兔肝脏脂肪代谢的影响。试验选用体重相似的断奶獭兔160只,随机分为4组,每组40个重复,每个重复1只。对照组獭兔饲喂基础饲粮,试验组獭兔分别饲喂在基础饲粮中添加10、20和40 mg/kg泛酸的饲粮。预试期7 d,正试期56 d。结果表明:与对照组相比,饲粮中添加40 mg/kg泛酸显著降低了生长獭兔肩胛、胃周和肾周脂肪沉积率(P0.05);饲粮中添加10~20 mg/kg泛酸显著降低了生长獭兔肝脏中脂滴的含量(P0.05)。饲粮中泛酸添加水平对生长獭兔血浆中总胆固醇和白蛋白的含量无显著影响(P0.05);随着饲粮中泛酸添加水平的升高,生长獭兔血浆中甘油三酯的含量先降低后趋于稳定,20、40 mg/kg添加组显著低于对照组(P0.05);与对照组相比,饲粮中添加20~40 mg/kg泛酸显著升高了生长獭兔血浆中极低密度脂蛋白的含量(P0.05)。与对照组相比,饲粮中添加40 mg/kg泛酸显著增加了肝脏中激素敏感脂酶(HSL)和骨骼肌中脂肪酸转运蛋白(FATP)基因的表达量(P0.05);饲粮中添加20~40 mg/kg泛酸显著增加了肝脏中肉毒碱棕榈酰转移酶1(CPT1)基因的表达量(P0.05);饲粮中添加10~40 mg/kg泛酸显著增加了肝脏中脂肪酸合成酶(FAS)基因和骨骼肌中CPT1基因的表达量(P0.05)。综上所述,饲粮中添加泛酸影响生长獭兔肝脏内脂肪代谢,泛酸添加水平为40 mg/kg时可降低肝脏内脂肪的沉积,并能降低机体脂肪沉积率,增加骨骼肌对脂肪酸的摄取和利用。
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| 关 键 词： | 獭兔 泛酸 肝脏 脂肪代谢 |
Effects of Pantothenic Acid Supplementation on Lipid Metabolism in Liver of Growing Rex Rabbits |
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| LIU Lei,ZHAO Nan,ZHANG Bin,LI Fuchang.Effects of Pantothenic Acid Supplementation on Lipid Metabolism in Liver of Growing Rex Rabbits[J].Acta Zoonutrimenta Sinica,2017,29(6). |
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| Authors: | LIU Lei ZHAO Nan ZHANG Bin LI Fuchang |
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| Abstract: | This experiment was conducted to investigate the effects of pantothenic acid supplementation on lipid metabolism in liver of growing Rex rabbits.A total of 160 weaned Rex rabbits with the similar body weight of were randomly divided into 4 groups with 40 replicates per group and 1 rabbit per replicate.Rabbits in the control group were fed a basal diet, and the others in the experimental groups were fed the basal diet supplemented with 10, 20 and 40 mg/kg pantothenic acid, respectively.The pre-test period lasted for 7 days, and the experimental period lasted for 53 days.The results showed that dietary supplemented with 40 mg/kg pantothenic acid significantly increased the scapular fat deposition rate, perigastric fat deposition rate and perirenal fat deposition rate of growing Rex rabbits (P<0.05), and dietary supplemented with 10 to 20 mg/kg pantothenic acid significantly decreased the liver fat droplet content of growing Rex rabbits compared with control group (P<0.05).Dietary pantothenic acid supplemental level had no significant effects on plasma total cholesterol and albumin contents of growing Rex rabbits (P>0.05).With the pantothenic acid supplemental level increasing, the plasma triglyceride content of growing Rex rabbits tended to reduce first and then became stable, and it in 20 and 40 mg/kg supplemental groups was significantly lower than that in control group (P<0.05).Compared with control group, dietary supplemented with 20 to 40 mg/kg pantothenic acid significantly increased the plasma very low density lipoprotein content of growing Rex rabbits (P<0.05).Compared with control group, dietary supplemented with 40 mg/kg pantothenic acid significantly increased the expression levels of hormone-sensitive lipase (HSL) gene in liver and fatty acid transport protein (FATP) gene in skeletal muscle (P<0.05), dietary supplemented with 20 to 40 mg/kg pantothenic acid significantly increased the expression level of carnitine palmityl transferase-1 (CPT1) gene in liver (P<0.05), and dietary supplemented with 10 to 40 mg/kg pantothenic acid significantly increased the expression levels of fatty acid synthase (FAS) gene and CPT1 gene in skeletal muscle (P<0.05).In conclusion, pantothenic acid supplementation affects the lipid metabolism in liver of Rex rabbits.Pantothenic acid with the supplemental level of 40 mg/kg can decrease the lipid deposition in liver and the fat deposition rate of body, and increase the uptake and utilization of fatty acids for skeletal muscle. |
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| Keywords: | Rex rabbits pantothenic acid liver lipid metabolism |
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