| 鲫鱼冬瓜皮汤改善肾病综合征患者水肿及肾功能的临床观察 |
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| 作者姓名： | 蔡亚宏 陈新宇 冯进 刘倩 艾曼娜 杨楠 |
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| 作者单位： | 湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007 |
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| 基金项目： | 湖南省中医药管理局一般项目（2017102） |
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| 摘 要： | 目的 观察鲫鱼冬瓜皮汤辅助治疗肾病综合征水肿期患者对水肿及肾功能的影响。方法 将120例肾病综合征患者随机分为两组各60例，对照组予以常规西药治疗，治疗组除常规西药治疗外，予以鲫鱼冬瓜皮汤，每日2次，隔日1剂，连续14 d为1疗程，共治疗2个疗程。观察两组患者水肿消退时间、腿围、腹围、体质量及血清肌酐（CR）、尿素氮（BUN）、尿酸（UA）水平的变化。结果 治疗组较对照组水肿消退时间明显缩短（P<0.05）；治疗4周后，两组患者的腿围、腹围及体质量较治疗前均明显降低（P<0.05），且治疗组腹围及体质量下降更明显（P<0.05）；治疗组血清CR、BUN、UA水平较治疗前显著下降（P<0.05），与对照组比较差异有统计学意义（P<0.05）。结论 鲫鱼冬瓜皮汤辅助治疗肾病综合征水肿患者可有效改善水肿及肾功能，疗效确切，食用安全，可在临床上进一步推广。
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| 关 键 词： | 肾病综合征 鲫鱼冬瓜皮汤 水肿 肾功能 |
| 收稿时间： | 2018/5/24 0:00:00 |
Clinical Observation on Improving Edema and Renal Function of Patients with Nephrotic Syndrome by Jiyu Dongguangpi Decoction |
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| Authors: | CAI Yahong CHEN Xinyu FENG Jin LIU Qian AI Manna and YANG Nan |
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| Institution: | The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China and The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China |
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| Abstract: | Objective To observe the effects of Jiyu Dongguapi Decoction on edema and renal function in patients with nephrotic syndrome at edema period. Methods A total of 120 patients with nephrotic syndrome were randomly divided into 2 groups, with 60 cases in each group. The control group was treated with conventional western medicine, and the treatment group was treated with Jiyu Dongguapi Decoction, in addition to the routine treatment of western medicine, twice a day, one dose every other day, 14 consecutive days as a course of treatment, a total of 2 courses of treatment. The changes of edema subsidence time, leg circumference, abdominal circumference, body weight and serum creatinine (CR), blood urea nitrogen (BUN), uric acid (UA) were observed. Results The time of edema subsidence in the treatment group was significantly shorter than that in the control group (P<0.05); after 4 weeks of treatment, the leg circumference, abdominal circumference and body weight of the 2 groups were significantly lower than those before treatment (P<0.05), and the abdominal circumference and body weight in the treatment group were significantly lower than those before treatment (P<0.05); the levels of serum CR, BUN and UA in the treatment group were significantly lower than those before treatment (P<0.05). There were significant differences comparing with control group (P<0.05). Conclusion Jiyu Dongguapi Decoction can effectively improve the edema and renal function of patients with nephrotic syndrome edema, which is effective and safe to eat, and it can be further promoted in clinical practice. |
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| Keywords: | nephrotic syndrome Jiyu Dongguapi Decoction edema renal function |
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