| 银杏叶提取物对大鼠脾脏免疫细胞凋亡相关蛋白Bcl-2和Bax表达的影响 |
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| 引用本文： | 何玉龙,范光丽,吴月红,阿依木古丽,田光明,王根辈.银杏叶提取物对大鼠脾脏免疫细胞凋亡相关蛋白Bcl-2和Bax表达的影响[J].中国兽医学报,2007,27(2):237-239. |
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| 作者姓名： | 何玉龙 范光丽 吴月红 阿依木古丽 田光明 王根辈 |
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| 作者单位： | 西北农林科技大学,动物科技学院,陕西,杨凌,712100 |
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| 摘 要： | 24只SD雌性大鼠随机分为假手术组(A组)、卵巢摘除组(B组)、卵巢摘除并银杏叶提取物(EGb)治疗组(C组),利用免疫组化染色检测脾脏中Bcl-2蛋白和Bax蛋白的表达.结果发现,B组大鼠脾脏内Bcl-2蛋白表达显著减少,而Bax蛋白表达显著增加;C组Bcl-2蛋白表达明显回升(P＜0.01),而Bax蛋白表达明显回落(P＜0.05).表明银杏叶提取物可通过上调Bcl-2蛋白表达,下调Bax蛋白表达,改变Bcl-2与Bax的比值(Bcl-2/Bax)而维护脾脏的免疫自稳状态.
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| 关 键 词： | 银杏叶提取物 卵巢摘除 脾脏 免疫自稳状态 |
| 文章编号： | 1005-4545(2007)02-0237-03 |
| 修稿时间： | 2005年4月11日 |
Effects of extract of Ginkgo biloba(Egb) on immunocyte apoptosis relevant proteins Bcl-2 and Bax in spleen of rat |
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| HE Yu-long,FAN Guang-li,WU Yue-hong,Ayimuguli,TIAN Guang-ming,WANG Gen-bei.Effects of extract of Ginkgo biloba(Egb) on immunocyte apoptosis relevant proteins Bcl-2 and Bax in spleen of rat[J].Chinese Journal of Veterinary Science,2007,27(2):237-239. |
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| Authors: | HE Yu-long FAN Guang-li WU Yue-hong Ayimuguli TIAN Guang-ming WANG Gen-bei |
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| Abstract: | Using SP immunohistochemistry staining to explore the effect of EGb on Bcl-2 and Bax positive expression in spleen of ovariectomized rats.24 SD rats were divided into 3 groups:the shamming operated group(A),ovariectomized group(B),and the ovariectomized and EGb treated group(C).As the result,the expression of Bcl-2 decreased,while the expression of Bax increased in ovariectomized group;on the contrary,the expression of Bcl-2 increased(P<0.01) and the expression of Bax decreased(P<0.05) in the ovariectomized and EGb treated group.These results indicated that EGb enable the spleen to maintain its immunologic homeostasis by upregulating the expression of Bcl-2 and downregulating the expression of Bax. |
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| Keywords: | Bcl-2 Bax |
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