Bartonella henselae infection in a dog with recalcitrant ineffective erythropoiesis |
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| Authors: | Martin G Randell Nandhakumar Balakrishnan Rebekah Gunn‐Christie Andrew Mackin Edward B Breitschwerdt |
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| Institution: | 1. Somers Animal Hospital, Somers, NY, USA;2. Department of Clinical Sciences, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA;3. The Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA;4. Antech Diagnostics, Cary, NC, USA;5. Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA |
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| Abstract: | Ineffective erythropoiesis was diagnosed in an 8‐year‐old male castrated Labrador Retriever. Despite treatment with immunosuppressive therapy for suspected immune‐mediated erythrocyte maturation arrest, resolution of the nonregenerative anemia was not achieved. Following documentation of Bartonella henselae bacteremia by Bartonella alpha proteobacteria growth medium (BAPGM) enrichment blood culture, immunosuppressive therapy was discontinued, and the anemia resolved following prolonged antibiotic therapy. Bartonella immunofluorescent antibody testing was negative, whereas B henselae western blot was consistently positive. The contribution of B henselae bacteremia to ineffective erythropoiesis remains unknown; however, the potential role of B henselae in the pathophysiology of bone marrow dyscrasias warrants additional investigation. |
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| Keywords: |
Bartonella henselae
bone marrow dyscrasia immunosuppression ineffective erythropoiesis |
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